The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics

Cassandra Vieten, Kimberly L. Seaton, Heidi Feiler, Kirk C. Wilhelmsen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: The University of California, San Francisco (UCSF) Family Alcoholism Study is a project designed to identify genetic loci that influence susceptibility to alcohol dependence and related phenotypes. Evidence supports a substantial genetic contribution to alcoholism susceptibility. However, the genetic epidemiology of alcoholism is complex, and its clinical manifestation is heterogeneous, making phenotype definition and demonstration of linkage difficult. Despite these challenges, some progress has been made toward identifying genes. Methods: The UCSF Family Alcoholism Study used a small family design, focusing primarily on sibling pairs and parent-child trios for linkage and association studies. Alcoholism-related phenotypes were assessed through interview and self-report questionnaires, with a focus on unidimensional and subphenotypical traits. Data-driven approaches to determining the most promising phenotypes for genetic analysis are being used. Both genome-wide scan and candidate gene approaches were used. Results: The study enrolled 2154 individuals from 970 families from December 1995 through January 2003. Test-retest and interrater reliability for clinical data are very good, and power estimates suggest that this study will have adequate power by linkage analysis to detect loci with moderate effects. Design, methods, and sample demographics of the UCSF Family Study are presented, along with intrafamilial correlations for primary diagnostic phenotypes. Conclusions: Plans for genetic analysis, novel approaches to phenotype refinement, and the implications of ascertainment bias for heritability estimates are discussed.

Original languageEnglish (US)
Pages (from-to)1509-1516
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume28
Issue number10
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

San Francisco
Alcoholism
Genes
Demography
Phenotype
Demonstrations
Alcohols
Genetic Loci
Molecular Epidemiology
Reproducibility of Results
Self Report
Siblings
Genome
Interviews

Keywords

  • Alcohol Dependence
  • Alcoholism
  • Family Study
  • Genetics
  • Linkage

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics. / Vieten, Cassandra; Seaton, Kimberly L.; Feiler, Heidi; Wilhelmsen, Kirk C.

In: Alcoholism: Clinical and Experimental Research, Vol. 28, No. 10, 10.2004, p. 1509-1516.

Research output: Contribution to journalArticle

@article{d6fc134655ff4e3eba963c789333f177,
title = "The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics",
abstract = "Background: The University of California, San Francisco (UCSF) Family Alcoholism Study is a project designed to identify genetic loci that influence susceptibility to alcohol dependence and related phenotypes. Evidence supports a substantial genetic contribution to alcoholism susceptibility. However, the genetic epidemiology of alcoholism is complex, and its clinical manifestation is heterogeneous, making phenotype definition and demonstration of linkage difficult. Despite these challenges, some progress has been made toward identifying genes. Methods: The UCSF Family Alcoholism Study used a small family design, focusing primarily on sibling pairs and parent-child trios for linkage and association studies. Alcoholism-related phenotypes were assessed through interview and self-report questionnaires, with a focus on unidimensional and subphenotypical traits. Data-driven approaches to determining the most promising phenotypes for genetic analysis are being used. Both genome-wide scan and candidate gene approaches were used. Results: The study enrolled 2154 individuals from 970 families from December 1995 through January 2003. Test-retest and interrater reliability for clinical data are very good, and power estimates suggest that this study will have adequate power by linkage analysis to detect loci with moderate effects. Design, methods, and sample demographics of the UCSF Family Study are presented, along with intrafamilial correlations for primary diagnostic phenotypes. Conclusions: Plans for genetic analysis, novel approaches to phenotype refinement, and the implications of ascertainment bias for heritability estimates are discussed.",
keywords = "Alcohol Dependence, Alcoholism, Family Study, Genetics, Linkage",
author = "Cassandra Vieten and Seaton, {Kimberly L.} and Heidi Feiler and Wilhelmsen, {Kirk C.}",
year = "2004",
month = "10",
doi = "10.1097/01.ALC.0000142261.32980.64",
language = "English (US)",
volume = "28",
pages = "1509--1516",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics

AU - Vieten, Cassandra

AU - Seaton, Kimberly L.

AU - Feiler, Heidi

AU - Wilhelmsen, Kirk C.

PY - 2004/10

Y1 - 2004/10

N2 - Background: The University of California, San Francisco (UCSF) Family Alcoholism Study is a project designed to identify genetic loci that influence susceptibility to alcohol dependence and related phenotypes. Evidence supports a substantial genetic contribution to alcoholism susceptibility. However, the genetic epidemiology of alcoholism is complex, and its clinical manifestation is heterogeneous, making phenotype definition and demonstration of linkage difficult. Despite these challenges, some progress has been made toward identifying genes. Methods: The UCSF Family Alcoholism Study used a small family design, focusing primarily on sibling pairs and parent-child trios for linkage and association studies. Alcoholism-related phenotypes were assessed through interview and self-report questionnaires, with a focus on unidimensional and subphenotypical traits. Data-driven approaches to determining the most promising phenotypes for genetic analysis are being used. Both genome-wide scan and candidate gene approaches were used. Results: The study enrolled 2154 individuals from 970 families from December 1995 through January 2003. Test-retest and interrater reliability for clinical data are very good, and power estimates suggest that this study will have adequate power by linkage analysis to detect loci with moderate effects. Design, methods, and sample demographics of the UCSF Family Study are presented, along with intrafamilial correlations for primary diagnostic phenotypes. Conclusions: Plans for genetic analysis, novel approaches to phenotype refinement, and the implications of ascertainment bias for heritability estimates are discussed.

AB - Background: The University of California, San Francisco (UCSF) Family Alcoholism Study is a project designed to identify genetic loci that influence susceptibility to alcohol dependence and related phenotypes. Evidence supports a substantial genetic contribution to alcoholism susceptibility. However, the genetic epidemiology of alcoholism is complex, and its clinical manifestation is heterogeneous, making phenotype definition and demonstration of linkage difficult. Despite these challenges, some progress has been made toward identifying genes. Methods: The UCSF Family Alcoholism Study used a small family design, focusing primarily on sibling pairs and parent-child trios for linkage and association studies. Alcoholism-related phenotypes were assessed through interview and self-report questionnaires, with a focus on unidimensional and subphenotypical traits. Data-driven approaches to determining the most promising phenotypes for genetic analysis are being used. Both genome-wide scan and candidate gene approaches were used. Results: The study enrolled 2154 individuals from 970 families from December 1995 through January 2003. Test-retest and interrater reliability for clinical data are very good, and power estimates suggest that this study will have adequate power by linkage analysis to detect loci with moderate effects. Design, methods, and sample demographics of the UCSF Family Study are presented, along with intrafamilial correlations for primary diagnostic phenotypes. Conclusions: Plans for genetic analysis, novel approaches to phenotype refinement, and the implications of ascertainment bias for heritability estimates are discussed.

KW - Alcohol Dependence

KW - Alcoholism

KW - Family Study

KW - Genetics

KW - Linkage

UR - http://www.scopus.com/inward/record.url?scp=6344249468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6344249468&partnerID=8YFLogxK

U2 - 10.1097/01.ALC.0000142261.32980.64

DO - 10.1097/01.ALC.0000142261.32980.64

M3 - Article

C2 - 15597083

AN - SCOPUS:6344249468

VL - 28

SP - 1509

EP - 1516

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 10

ER -