The tyrosine kinase activity of the chicken insulin receptor is similar to that of the human insulin receptor

Hisanori Kato, Yumiko Okubo, Yuki Matsumura, Charles T. Roberts, Kunio Sugahara, Derek Leroith

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    11 Scopus citations

    Abstract

    The tyrosine kinase activity of a chimeric insulin receptor composed of the extracellular domain of the human insulin receptor (IR) and the intracellular domain of the chicken IR was compared with wild-type human IR. The degrees of autophosphorylation, phosphorylation of IRS-1, and in vitro phosphorylation of an exogenous substrate after stimulation by human insulin were similar to that seen with the human IR. We conclude that the insulin resistance of chickens is not attributable to a lower level of intrinsic tyrosine kinase activity of IR.

    Original languageEnglish (US)
    Pages (from-to)903-906
    Number of pages4
    JournalBioscience, Biotechnology and Biochemistry
    Volume64
    Issue number4
    DOIs
    StatePublished - Jan 1 2000

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    Keywords

    • Chicken
    • IRS-1
    • Insulin receptor
    • Tyrosine kinase

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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