The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

Eric Alix, Camilla Godlee, Ondrej Cerny, Samkeliso Blundell, Romina Tocci, Sophie Matthews, Mei Liu, Jonathan N. Pruneda, Kirby N. Swatek, David Komander, Tabitha Sleap, David W. Holden

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Salmonella inhibits the adaptive immune response by reducing cell surface levels of mature MHC class II. Alix et al. reveal that the Salmonella effector SteD co-opts TMEM127, a tumor suppressor protein of previously unknown function. TMEM127 binds the E3 ubiquitin ligase WWP2 enabling ubiquitination and degradation of MHCII and SteD.

Original languageEnglish (US)
Pages (from-to)54-68.e7
JournalCell Host and Microbe
Volume28
Issue number1
DOIs
StatePublished - Jul 8 2020

Keywords

  • CRISPR screen
  • MHCII
  • Salmonella
  • SteD
  • TMEM127
  • WWP2
  • dendritic cells
  • lysosomal degradation
  • ubiquitination

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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