The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

Eric Alix; Camilla Godlee; Ondrej Cerny; Samkeliso Blundell; Romina Tocci; Sophie Matthews; Mei Liu; Jonathan N. Pruneda; Kirby N. Swatek; David Komander; Tabitha Sleap; David W. Holden

doi:10.1016/j.chom.2020.04.024

The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

Eric Alix, Camilla Godlee, Ondrej Cerny, Samkeliso Blundell, Romina Tocci, Sophie Matthews, Mei Liu, Jonathan N. Pruneda, Kirby N. Swatek, David Komander, Tabitha Sleap, David W. Holden

Molecular Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Salmonella inhibits the adaptive immune response by reducing cell surface levels of mature MHC class II. Alix et al. reveal that the Salmonella effector SteD co-opts TMEM127, a tumor suppressor protein of previously unknown function. TMEM127 binds the E3 ubiquitin ligase WWP2 enabling ubiquitination and degradation of MHCII and SteD.

Original language	English (US)
Pages (from-to)	54-68.e7
Journal	Cell Host and Microbe
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.chom.2020.04.024
State	Published - Jul 8 2020

Keywords

CRISPR screen
MHCII
Salmonella
SteD
TMEM127
WWP2
dendritic cells
lysosomal degradation
ubiquitination

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2020.04.024

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Alix, E., Godlee, C., Cerny, O., Blundell, S., Tocci, R., Matthews, S., Liu, M., Pruneda, J. N., Swatek, K. N., Komander, D., Sleap, T., & Holden, D. W. (2020). The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules. Cell Host and Microbe, 28(1), 54-68.e7. https://doi.org/10.1016/j.chom.2020.04.024

Alix, E, Godlee, C, Cerny, O, Blundell, S, Tocci, R, Matthews, S, Liu, M, Pruneda, JN, Swatek, KN, Komander, D, Sleap, T & Holden, DW 2020, 'The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules', Cell Host and Microbe, vol. 28, no. 1, pp. 54-68.e7. https://doi.org/10.1016/j.chom.2020.04.024

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title = "The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules",

abstract = "Salmonella inhibits the adaptive immune response by reducing cell surface levels of mature MHC class II. Alix et al. reveal that the Salmonella effector SteD co-opts TMEM127, a tumor suppressor protein of previously unknown function. TMEM127 binds the E3 ubiquitin ligase WWP2 enabling ubiquitination and degradation of MHCII and SteD.",

keywords = "CRISPR screen, MHCII, Salmonella, SteD, TMEM127, WWP2, dendritic cells, lysosomal degradation, ubiquitination",

author = "Eric Alix and Camilla Godlee and Ondrej Cerny and Samkeliso Blundell and Romina Tocci and Sophie Matthews and Mei Liu and Pruneda, {Jonathan N.} and Swatek, {Kirby N.} and David Komander and Tabitha Sleap and Holden, {David W.}",

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doi = "10.1016/j.chom.2020.04.024",

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T1 - The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

AU - Alix, Eric

AU - Godlee, Camilla

AU - Cerny, Ondrej

AU - Blundell, Samkeliso

AU - Tocci, Romina

AU - Matthews, Sophie

AU - Liu, Mei

AU - Pruneda, Jonathan N.

AU - Swatek, Kirby N.

AU - Komander, David

AU - Sleap, Tabitha

AU - Holden, David W.

PY - 2020/7/8

Y1 - 2020/7/8

N2 - Salmonella inhibits the adaptive immune response by reducing cell surface levels of mature MHC class II. Alix et al. reveal that the Salmonella effector SteD co-opts TMEM127, a tumor suppressor protein of previously unknown function. TMEM127 binds the E3 ubiquitin ligase WWP2 enabling ubiquitination and degradation of MHCII and SteD.

AB - Salmonella inhibits the adaptive immune response by reducing cell surface levels of mature MHC class II. Alix et al. reveal that the Salmonella effector SteD co-opts TMEM127, a tumor suppressor protein of previously unknown function. TMEM127 binds the E3 ubiquitin ligase WWP2 enabling ubiquitination and degradation of MHCII and SteD.

KW - CRISPR screen

KW - MHCII

KW - Salmonella

KW - SteD

KW - TMEM127

KW - WWP2

KW - dendritic cells

KW - lysosomal degradation

KW - ubiquitination

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The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

Abstract

Keywords

ASJC Scopus subject areas

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