The tumor-immune microenvironment and response to radiation therapy

Stephen L. Shiao, Lisa M. Coussens

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations

Abstract

Chemotherapy and radiation therapy (RT) are standard therapeutic modalities for patients with cancer, including breast cancer. Historic studies examining tissue and cellular responses to RT have predominantly focused on damage caused to proliferating malignant cells leading to their death. However, there is increasing evidence that RT also leads to significant alterations in the tumor microenvironment, particularly with respect to effects on immune cells infiltrating tumors. This review focuses on tumor-associated immune cell responses following RTand discusses how immune responses may be modified to enhance durability and efficacy of RT.

Original languageEnglish (US)
Pages (from-to)411-421
Number of pages11
JournalJournal of Mammary Gland Biology and Neoplasia
Volume15
Issue number4
DOIs
StatePublished - Dec 2010

Keywords

  • Cancer
  • Immune cell
  • Inflammation
  • Leukocytes
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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