The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

Ma Wan, Jiancong Liang, Yuanyan Xiong, Fengtao Shi, Yi Zhang, Weisi Lu, Quanyuan He, Dong Yang, Rui Chen, Dan Liu, Michelle Barton, Zhou Songyang

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Background: The trithorax protein Ash2l is a core component of the MLL complex essential for H3K4 methylation and mouse embryonic development. Results: Ash2l depletion promotes differentiation and chromatin compaction. Conclusion: Ash2l is essential for pluripotency and open chromatin in mouse ES cells. Significance: This work describes for the first time genome-wide localization of Ash2l and provides insight into how open chromatin is maintained in ES cells.

Original languageEnglish (US)
Pages (from-to)5039-5048
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
StatePublished - Feb 15 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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