The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

Ma Wan; Jiancong Liang; Yuanyan Xiong; Fengtao Shi; Yi Zhang; Weisi Lu; Quanyuan He; Dong Yang; Rui Chen; Dan Liu; Michelle Barton; Zhou Songyang

doi:10.1074/jbc.M112.424515

The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

Ma Wan, Jiancong Liang, Yuanyan Xiong, Fengtao Shi, Yi Zhang, Weisi Lu, Quanyuan He, Dong Yang, Rui Chen, Dan Liu, Michelle Barton, Zhou Songyang

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Background: The trithorax protein Ash2l is a core component of the MLL complex essential for H3K4 methylation and mouse embryonic development. Results: Ash2l depletion promotes differentiation and chromatin compaction. Conclusion: Ash2l is essential for pluripotency and open chromatin in mouse ES cells. Significance: This work describes for the first time genome-wide localization of Ash2l and provides insight into how open chromatin is maintained in ES cells.

Original language	English (US)
Pages (from-to)	5039-5048
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.424515
State	Published - Feb 15 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.424515

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abstract = "Background: The trithorax protein Ash2l is a core component of the MLL complex essential for H3K4 methylation and mouse embryonic development. Results: Ash2l depletion promotes differentiation and chromatin compaction. Conclusion: Ash2l is essential for pluripotency and open chromatin in mouse ES cells. Significance: This work describes for the first time genome-wide localization of Ash2l and provides insight into how open chromatin is maintained in ES cells.",

author = "Ma Wan and Jiancong Liang and Yuanyan Xiong and Fengtao Shi and Yi Zhang and Weisi Lu and Quanyuan He and Dong Yang and Rui Chen and Dan Liu and Michelle Barton and Zhou Songyang",

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T1 - The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

AU - Wan, Ma

AU - Liang, Jiancong

AU - Xiong, Yuanyan

AU - Shi, Fengtao

AU - Zhang, Yi

AU - Lu, Weisi

AU - He, Quanyuan

AU - Yang, Dong

AU - Chen, Rui

AU - Liu, Dan

AU - Barton, Michelle

AU - Songyang, Zhou

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: The trithorax protein Ash2l is a core component of the MLL complex essential for H3K4 methylation and mouse embryonic development. Results: Ash2l depletion promotes differentiation and chromatin compaction. Conclusion: Ash2l is essential for pluripotency and open chromatin in mouse ES cells. Significance: This work describes for the first time genome-wide localization of Ash2l and provides insight into how open chromatin is maintained in ES cells.

AB - Background: The trithorax protein Ash2l is a core component of the MLL complex essential for H3K4 methylation and mouse embryonic development. Results: Ash2l depletion promotes differentiation and chromatin compaction. Conclusion: Ash2l is essential for pluripotency and open chromatin in mouse ES cells. Significance: This work describes for the first time genome-wide localization of Ash2l and provides insight into how open chromatin is maintained in ES cells.

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JO - Journal of Biological Chemistry

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IS - 7

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The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

Abstract

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