The transcription factor Bhlhb4 is required for rod bipolar cell maturation

Debra E. Bramblett, Mark Pennesi, Samuel M. Wu, Ming Jer Tsai

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expressed in rod bipolar cells (RB). Electroretinograms (ERGs) in the adult Bhlhb4 knockout (Bhlhb4-/-) showed that the loss of Bhlhb4 resulted in disrupted rod signaling and profound retinal dysfunction resembling human congenital stationary night blindness (CSNB), characterized by the loss of the scotopic ERG b-wave. A depletion of inner nuclear layer (INL) cells in the adult Bhlhb4 knockout has been ascribed to the abolishment of the RB cell population during postnatal development. Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4-/- mouse suggests that Bhlhb4 is essential for RB cell maturation.

Original languageEnglish (US)
Pages (from-to)779-793
Number of pages15
JournalNeuron
Volume43
Issue number6
DOIs
StatePublished - Sep 16 2004
Externally publishedYes

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Transcription Factors
Retinal Bipolar Cells
Basic Helix-Loop-Helix Transcription Factors
Blindness
Knockout Mice
Population
Light

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The transcription factor Bhlhb4 is required for rod bipolar cell maturation. / Bramblett, Debra E.; Pennesi, Mark; Wu, Samuel M.; Tsai, Ming Jer.

In: Neuron, Vol. 43, No. 6, 16.09.2004, p. 779-793.

Research output: Contribution to journalArticle

Bramblett, Debra E. ; Pennesi, Mark ; Wu, Samuel M. ; Tsai, Ming Jer. / The transcription factor Bhlhb4 is required for rod bipolar cell maturation. In: Neuron. 2004 ; Vol. 43, No. 6. pp. 779-793.
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