The time course of NMDA receptor-mediated synaptic currents

Robin A.J. Lester, John D. Clements, Gang Tong, Gary L. Westbrook, Craig E. Jahr

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The slowly rising, long-lasting time course of the NMDA receptor-mediated excitatory post-synaptic current (EPSC) is unusual for a response mediated by a directly gated ion channel. Although the EPSC time course has been physiologically reconciled with the role of the NMDA receptor in associative synaptic plasticity, until recently, the precise mechanisms underlying its generation remained obscure. This chapter focuses on how the interaction between synaptically released transmitter and the postsynaptic receptor gives rise to the distinctive properties of the NMDA synaptic current.

Original languageEnglish (US)
Title of host publicationThe NMDA Receptor
PublisherOxford University Press
ISBN (Electronic)9780191724701
ISBN (Print)9780192625021
DOIs
StatePublished - Mar 22 2012

Keywords

  • EPSC
  • Ion channels
  • NMDA receptors
  • Postsynaptic receptors
  • Synaptic currents
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Lester, R. A. J., Clements, J. D., Tong, G., Westbrook, G. L., & Jahr, C. E. (2012). The time course of NMDA receptor-mediated synaptic currents. In The NMDA Receptor Oxford University Press. https://doi.org/10.1093/acprof:oso/9780192625021.003.0008