The time course of NMDA receptor-mediated synaptic currents

Robin A.J. Lester; John D. Clements; Gang Tong; Gary L. Westbrook; Craig E. Jahr

doi:10.1093/acprof:oso/9780192625021.003.0008

The time course of NMDA receptor-mediated synaptic currents

Robin A.J. Lester, John D. Clements, Gang Tong, Gary L. Westbrook, Craig E. Jahr

Vollum Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The slowly rising, long-lasting time course of the NMDA receptor-mediated excitatory post-synaptic current (EPSC) is unusual for a response mediated by a directly gated ion channel. Although the EPSC time course has been physiologically reconciled with the role of the NMDA receptor in associative synaptic plasticity, until recently, the precise mechanisms underlying its generation remained obscure. This chapter focuses on how the interaction between synaptically released transmitter and the postsynaptic receptor gives rise to the distinctive properties of the NMDA synaptic current.

Original language	English (US)
Title of host publication	The NMDA Receptor
Publisher	Oxford University Press
ISBN (Electronic)	9780191724701
ISBN (Print)	9780192625021
DOIs	https://doi.org/10.1093/acprof:oso/9780192625021.003.0008
State	Published - Mar 22 2012

Keywords

EPSC
Ion channels
NMDA receptors
Postsynaptic receptors
Synaptic currents
Synaptic plasticity

ASJC Scopus subject areas

General Neuroscience

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10.1093/acprof:oso/9780192625021.003.0008

Cite this

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AB - The slowly rising, long-lasting time course of the NMDA receptor-mediated excitatory post-synaptic current (EPSC) is unusual for a response mediated by a directly gated ion channel. Although the EPSC time course has been physiologically reconciled with the role of the NMDA receptor in associative synaptic plasticity, until recently, the precise mechanisms underlying its generation remained obscure. This chapter focuses on how the interaction between synaptically released transmitter and the postsynaptic receptor gives rise to the distinctive properties of the NMDA synaptic current.

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The time course of NMDA receptor-mediated synaptic currents

Abstract

Keywords

ASJC Scopus subject areas

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