The thymus-adrenal connection

Thymosin has corticotropin-releasing activity in primates

David L. Healy, Gary D. Hodgen, Heinrich M. Schulte, George P. Chrousos, Donald (Lynn) Loriaux, Nicholas R. Hall, Allan L. Goldstein

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Endotoxin-free thymosin fraction 5 elevated corticotropin, β-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys. Two synthetic component peptides of thymosin fraction 5 had no acute effects on pituitary function, suggesting that some other peptides in thymosin fraction 5 were responsible for its corticotropin-releasing activity. In agreement with these observations, total thymectomy of juvenile macaques was associated with decreases in plasma cortisol, corticotropin, and β-endorphin. These findings indicate that the prepubertal primate thymus contains corticotropin-releasing activity that may contribute to a physiological immunoregulatory circuit between the developing immunological and pituitary-adrenal systems.

Original languageEnglish (US)
Pages (from-to)1353-1355
Number of pages3
JournalScience
Volume222
Issue number4630
StatePublished - 1983
Externally publishedYes

Fingerprint

Thymosin
Adrenocorticotropic Hormone
Thymus Gland
Primates
Endorphins
Hydrocortisone
Pituitary-Adrenal System
Thymectomy
Peptides
Macaca fascicularis
Macaca
Endotoxins
thymosin fraction 5

ASJC Scopus subject areas

  • General

Cite this

Healy, D. L., Hodgen, G. D., Schulte, H. M., Chrousos, G. P., Loriaux, D. L., Hall, N. R., & Goldstein, A. L. (1983). The thymus-adrenal connection: Thymosin has corticotropin-releasing activity in primates. Science, 222(4630), 1353-1355.

The thymus-adrenal connection : Thymosin has corticotropin-releasing activity in primates. / Healy, David L.; Hodgen, Gary D.; Schulte, Heinrich M.; Chrousos, George P.; Loriaux, Donald (Lynn); Hall, Nicholas R.; Goldstein, Allan L.

In: Science, Vol. 222, No. 4630, 1983, p. 1353-1355.

Research output: Contribution to journalArticle

Healy, DL, Hodgen, GD, Schulte, HM, Chrousos, GP, Loriaux, DL, Hall, NR & Goldstein, AL 1983, 'The thymus-adrenal connection: Thymosin has corticotropin-releasing activity in primates', Science, vol. 222, no. 4630, pp. 1353-1355.
Healy DL, Hodgen GD, Schulte HM, Chrousos GP, Loriaux DL, Hall NR et al. The thymus-adrenal connection: Thymosin has corticotropin-releasing activity in primates. Science. 1983;222(4630):1353-1355.
Healy, David L. ; Hodgen, Gary D. ; Schulte, Heinrich M. ; Chrousos, George P. ; Loriaux, Donald (Lynn) ; Hall, Nicholas R. ; Goldstein, Allan L. / The thymus-adrenal connection : Thymosin has corticotropin-releasing activity in primates. In: Science. 1983 ; Vol. 222, No. 4630. pp. 1353-1355.
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