The terminal amino acids of protein sequences and protein maturation

John A. Black; Peter Stenzel; Richard N. Harkins

doi:10.1016/0022-5193(75)90030-2

The terminal amino acids of protein sequences and protein maturation

John A. Black, Peter Stenzel, Richard N. Harkins

Pathology

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Abstract

A comparison is made of the N- and C-terminal amino acids from 96 published protein sequences, 26 from prokaryotes, 70 from eukaryotes. The observed frequencies of the N-terminal amino acids methionine, alanine and serine in prokaryotes, and alanine and serine in eukaryotes are significantly higher than expected for a random arrangement of amino acids. At the C-terminal end, the observed frequencies of lysine, asparagine and glutamine in prokaryotes and phenylalanine, asparagine and glutamine in eukaryotes exceed random expectation. These results could be explained by specific proteolytic cleavage during protein synthesis.

Original language	English (US)
Pages (from-to)	161-166
Number of pages	6
Journal	Journal of Theoretical Biology
Volume	50
Issue number	1
DOIs	https://doi.org/10.1016/0022-5193(75)90030-2
State	Published - Mar 1975

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

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10.1016/0022-5193(75)90030-2

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AB - A comparison is made of the N- and C-terminal amino acids from 96 published protein sequences, 26 from prokaryotes, 70 from eukaryotes. The observed frequencies of the N-terminal amino acids methionine, alanine and serine in prokaryotes, and alanine and serine in eukaryotes are significantly higher than expected for a random arrangement of amino acids. At the C-terminal end, the observed frequencies of lysine, asparagine and glutamine in prokaryotes and phenylalanine, asparagine and glutamine in eukaryotes exceed random expectation. These results could be explained by specific proteolytic cleavage during protein synthesis.

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The terminal amino acids of protein sequences and protein maturation

Abstract

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