The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability

April L. Risinger; Mohan Natarajan; Charles R. Thomas; Susan L. Mooberry

doi:10.1016/j.canlet.2011.03.022

The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability

April L. Risinger, Mohan Natarajan, Charles R. Thomas, Susan L. Mooberry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The taccalonolides are novel antimitotic microtubule stabilizers that have a unique mechanism of action independent of a direct interaction with tubulin. Cytotoxicity and clonogenic assays show that taccalonolide A and radiation act in an additive manner to cause cell death. The taxanes and epothilones have utility when combined with radiotherapy and these findings further suggest the additive effects of microtubule targeting agents with radiation on cellular proliferation are independent of direct tubulin binding and are instead a result of the downstream effects of these agents. These studies suggest that diverse antimitotic agents, including the taccalonolides, may have utility in chemoradiotherapy.

Original language	English (US)
Pages (from-to)	104-111
Number of pages	8
Journal	Cancer Letters
Volume	307
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2011.03.022
State	Published - Aug 1 2011
Externally published	Yes

Keywords

Antimitotic
Microtubule stabilizer
Radio-sensitizer
Taccalonolide
γ-Radiation

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2011.03.022

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title = "The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability",

abstract = "The taccalonolides are novel antimitotic microtubule stabilizers that have a unique mechanism of action independent of a direct interaction with tubulin. Cytotoxicity and clonogenic assays show that taccalonolide A and radiation act in an additive manner to cause cell death. The taxanes and epothilones have utility when combined with radiotherapy and these findings further suggest the additive effects of microtubule targeting agents with radiation on cellular proliferation are independent of direct tubulin binding and are instead a result of the downstream effects of these agents. These studies suggest that diverse antimitotic agents, including the taccalonolides, may have utility in chemoradiotherapy.",

keywords = "Antimitotic, Microtubule stabilizer, Radio-sensitizer, Taccalonolide, γ-Radiation",

author = "Risinger, {April L.} and Mohan Natarajan and Thomas, {Charles R.} and Mooberry, {Susan L.}",

note = "Funding Information: Grant support: NCI R01 CA121138 (S.L.M.), DOD-CDMRP Postdoctoral award BC087466 (A.L.R.), NCI RO1 CA112175 (M.N.) and the NCI P30 CA054174 (S.L.M. and M.N.). ",

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language = "English (US)",

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AU - Risinger, April L.

AU - Natarajan, Mohan

AU - Thomas, Charles R.

AU - Mooberry, Susan L.

N1 - Funding Information: Grant support: NCI R01 CA121138 (S.L.M.), DOD-CDMRP Postdoctoral award BC087466 (A.L.R.), NCI RO1 CA112175 (M.N.) and the NCI P30 CA054174 (S.L.M. and M.N.).

PY - 2011/8/1

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N2 - The taccalonolides are novel antimitotic microtubule stabilizers that have a unique mechanism of action independent of a direct interaction with tubulin. Cytotoxicity and clonogenic assays show that taccalonolide A and radiation act in an additive manner to cause cell death. The taxanes and epothilones have utility when combined with radiotherapy and these findings further suggest the additive effects of microtubule targeting agents with radiation on cellular proliferation are independent of direct tubulin binding and are instead a result of the downstream effects of these agents. These studies suggest that diverse antimitotic agents, including the taccalonolides, may have utility in chemoradiotherapy.

AB - The taccalonolides are novel antimitotic microtubule stabilizers that have a unique mechanism of action independent of a direct interaction with tubulin. Cytotoxicity and clonogenic assays show that taccalonolide A and radiation act in an additive manner to cause cell death. The taxanes and epothilones have utility when combined with radiotherapy and these findings further suggest the additive effects of microtubule targeting agents with radiation on cellular proliferation are independent of direct tubulin binding and are instead a result of the downstream effects of these agents. These studies suggest that diverse antimitotic agents, including the taccalonolides, may have utility in chemoradiotherapy.

KW - Antimitotic

KW - Microtubule stabilizer

KW - Radio-sensitizer

KW - Taccalonolide

KW - γ-Radiation

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The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability

Abstract

Keywords

ASJC Scopus subject areas

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