@article{f3833c1854d74d6ca320332a7cdfc0ab,
title = "The Systems Biology Graphical Notation",
abstract = "Circuit diagrams and Unified Modeling Language diagrams are just two examples of standard visual languages that help accelerate work by promoting regularity, removing ambiguity and enabling software tool support for communication of complex information. Ironically, despite having one of the highest ratios of graphical to textual information, biology still lacks standard graphical notations. The recent deluge of biological knowledge makes addressing this deficit a pressing concern. Toward this goal, we present the Systems Biology Graphical Notation (SBGN), a visual language developed by a community of biochemists, modelers and computer scientists. SBGN consists of three complementary languages: process diagram, entity relationship diagram and activity flow diagram. Together they enable scientists to represent networks of biochemical interactions in a standard, unambiguous way. We believe that SBGN will foster efficient and accurate representation, visualization, storage, exchange and reuse of information on all kinds of biological knowledge, from gene regulation, to metabolism, to cellular signaling.",
author = "Nov{\`e}re, {Nicolas Le} and Michael Hucka and Huaiyu Mi and Stuart Moodie and Falk Schreiber and Anatoly Sorokin and Emek Demir and Katja Wegner and Aladjem, {Mirit I.} and Wimalaratne, {Sarala M.} and Bergman, {Frank T.} and Ralph Gauges and Peter Ghazal and Hideya Kawaji and Lu Li and Yukiko Matsuoka and Alice Vill{\'e}ger and Boyd, {Sarah E.} and Laurence Calzone and Melanie Courtot and Ugur Dogrusoz and Freeman, {Tom C.} and Akira Funahashi and Samik Ghosh and Akiya Jouraku and Sohyoung Kim and Fedor Kolpakov and Augustin Luna and Sven Sahle and Esther Schmidt and Steven Watterson and Guanming Wu and Igor Goryanin and Kell, {Douglas B.} and Chris Sander and Herbert Sauro and Snoep, {Jacky L.} and Kurt Kohn and Hiroaki Kitano",
note = "Funding Information: In the version of this article initially published, the following acknowledgment was inadvertently left out: “The UCSF CPTAC team gratefully acknowledges the support of the Canary Foundation for providing funds to purchase a 4000 QTRAP mass spectrometer.” The acknowlegment has been added to the HTML and PDF versions of the article. Funding Information: The development of SBGN was mainly supported by a grant from the New Energy and Industrial Technology Development Organization of the Japanese government. SBGN workshops also benefited from funding by the following organizations: the UK Biotechnology and Biological Sciences Research Council, the National Institute of Advanced Industrial Science and Technology of Japan, the Okinawa Institute of Science and Technology), the European Media Laboratory, Heidelberg, Germany and the Beckman Institute at the California Institute of Technology, Pasadena, California, USA. Attendance at the meetings by Japanese authors was supported by the Japan Science and Technology Agency and by the genome network project of the Japanese Ministry of Education, Culture, Sports, Science, and Technology. I.G., S.M. and A.S. acknowledge support by the British Engineering and Physical Sciences Research Council. F.T.B. acknowledges support by the National Institutes of Health (NIH; grant 1R01GM081070-01). The contributions of M.I.A., S.K., A.L. and K.K. were supported by the Intramural Research Program of the NIH, Center for Cancer Research, National Cancer Institute (NIH).",
year = "2009",
month = aug,
doi = "10.1038/nbt.1558",
language = "English (US)",
volume = "27",
pages = "735--741",
journal = "Biotechnology",
issn = "1087-0156",
publisher = "Nature Publishing Group",
number = "8",
}