Abstract
Thyroid hormones undergo extensive metabolism to regulate hormone activity. A labeled thyroid hormone would be useful to track hormone metabolism through various pathways. While radiolabeled thyroid hormones have been synthesized and used for in vivo studies, a stable isotope labeled form of thyroid hormone is required for studying thyroid hormone metabolism by LC-MS/MS, an analytical technique that has certain advantages without the complications of radioactivity. Here we report the synthesis of 13C9- 15N-T2 and 13C9-15N- T4, two labeled thyroid hormone derivatives suitable for in vivo LC-MS/MS studies. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.
Original language | English (US) |
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Pages (from-to) | 1439-1446 |
Number of pages | 8 |
Journal | Synthetic Communications |
Volume | 43 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2013 |
Keywords
- C -N-T
- C-N-T
- Thyroid hormone
- Thyroxine
ASJC Scopus subject areas
- Organic Chemistry