The syndrome of inappropriate antidiuresis

David H. Ellison, Tomas Berl

Research output: Contribution to journalArticlepeer-review

706 Scopus citations


A 62-year-old woman noted an unpleasant, sweet taste in her mouth. She otherwise felt well and was taking no medications. Because dysgeusia is a rare manifestation of hyponatremia, her serum sodium level was tested and was 122 mmol per liter. The serum osmolality was 250 mOsm per kilogram of water, the urinary osmolality 635 mOsm per kilogram of water, the urinary sodium 85 mmol per liter, and the urinary potassium 40 mmol per liter. Her thyroid function and adrenal function were normal. A computed tomographic (CT) scan of the thorax showed a mass in the lower lobe of the left lung, which proved to be a small-cell carcinoma. How should her hyponatremia be treated?

Original languageEnglish (US)
Pages (from-to)2064-2072
Number of pages9
JournalNew England Journal of Medicine
Issue number20
StatePublished - May 17 2007

ASJC Scopus subject areas

  • Medicine(all)


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