The switch from fetal to adult hemoglobin in humans: evidence suggesting a role for γ β gene linkage

David Kabat

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This research was designed to distinguish between 2 alternative models for regulation of the chromosomal region that contains the genes for human non α globin chains: Leaky Model and Mutually Exclusive Model. This paper describes the author's attempts to analyze the distributions of hemoglobins A, F, and S among erythrocytes from the umbilical cords of newborn A/S heterozygotes. The analysis is based on use of 3 different specific staining techniques. This work confirms earlier reports that transitional stage erythrocytes, which contain both fetal and adult hemoglobins, occur in cord blood of newborn babies. The analyses of A/S cord bloods are consistent with the Mutually Exclusive Model and appear to be inconsistent with the Leaky Model of globin gene regulation.

Original languageEnglish (US)
Pages (from-to)119-131
Number of pages13
JournalAnnals of the New York Academy of Sciences
VolumeVol 241
StatePublished - 1974

Fingerprint

Fetal Hemoglobin
Globins
Fetal Blood
Hemoglobins
Genes
Erythrocytes
Switches
Hemoglobin A
Sickle Hemoglobin
Umbilical Cord
Heterozygote
Staining and Labeling
Blood
Research
Gene expression
Linkage
Hemoglobin
Gene
Cord

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The switch from fetal to adult hemoglobin in humans : evidence suggesting a role for γ β gene linkage. / Kabat, David.

In: Annals of the New York Academy of Sciences, Vol. Vol 241, 1974, p. 119-131.

Research output: Contribution to journalArticle

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