The Substantia Nigra Pars Reticulata in Sedative-Hypnotic Withdrawal

Lauren C. Kruse, Kari Buck

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sedative-hypnotic drugs including alcohol, benzodiazepines, and barbiturates, are widely used and abused for their euphoric and sedative properties. Sedative-hypnotic abuse and addiction is a complex, heterogeneous disorder, with biological (genetic) factors strongly influencing risk for dependence. Physiological dependence and associated withdrawal are thought to be a powerful motivational force that perpetuates sedative-hypnotic use/abuse, and enhances vulnerability to relapse. Recently, the substantia nigra pars reticulata (SNr) has been identified as crucially involved in sedative-hypnotic withdrawal symptoms (e.g., convulsions). The Mpdz gene has been implicated in sedative-hypnotic physiological dependence and associated withdrawal episodes in mice, with Mpdz expression within the caudolateral subregion of the SNr crucially involved.

Original languageEnglish (US)
Title of host publicationGeneral Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions
PublisherElsevier Inc.
Pages345-355
Number of pages11
Volume3
ISBN (Electronic)9780128006771
ISBN (Print)9780128006344
DOIs
StatePublished - May 13 2016

Keywords

  • Alcohol
  • Barbiturate
  • Benzodiazepine
  • Dependence
  • GABA
  • Genetic
  • Mpdz
  • MUPP1
  • Sedative
  • Substantia nigra
  • Withdrawal

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Kruse, L. C., & Buck, K. (2016). The Substantia Nigra Pars Reticulata in Sedative-Hypnotic Withdrawal. In General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions (Vol. 3, pp. 345-355). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800634-4.00034-2