Abstract
In mammals, the initial bridge between the physical world of sound and perception of that sound is established by neurons of the spiral ganglion. The cell bodies of these neurons give rise to peripheral processes that contact acoustic receptors in the organ of Corti, and the central processes collect together to form the auditory nerve that projects into the brain. In order to better understand hearing at this initial stage, we need to know the following about spiral ganglion neurons: (1) their cell biology including cytoplasmic, cytoskeletal, and membrane properties, (2) their peripheral and central connections including synaptic structure; (3) the nature of their neural signaling; and (4) their capacity for plasticity and rehabilitation. In this report, we will update the progress on these topics and indicate important issues still awaiting resolution.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2-20 |
| Number of pages | 19 |
| Journal | Hearing Research |
| Volume | 278 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Aug 1 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Sensory Systems
Cite this
The spiral ganglion : Connecting the peripheral and central auditory systems. / Nayagam, Bryony A.; Muniak, Michael; Ryugo, David K.
In: Hearing Research, Vol. 278, No. 1-2, 01.08.2011, p. 2-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The spiral ganglion
T2 - Connecting the peripheral and central auditory systems
AU - Nayagam, Bryony A.
AU - Muniak, Michael
AU - Ryugo, David K.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - In mammals, the initial bridge between the physical world of sound and perception of that sound is established by neurons of the spiral ganglion. The cell bodies of these neurons give rise to peripheral processes that contact acoustic receptors in the organ of Corti, and the central processes collect together to form the auditory nerve that projects into the brain. In order to better understand hearing at this initial stage, we need to know the following about spiral ganglion neurons: (1) their cell biology including cytoplasmic, cytoskeletal, and membrane properties, (2) their peripheral and central connections including synaptic structure; (3) the nature of their neural signaling; and (4) their capacity for plasticity and rehabilitation. In this report, we will update the progress on these topics and indicate important issues still awaiting resolution.
AB - In mammals, the initial bridge between the physical world of sound and perception of that sound is established by neurons of the spiral ganglion. The cell bodies of these neurons give rise to peripheral processes that contact acoustic receptors in the organ of Corti, and the central processes collect together to form the auditory nerve that projects into the brain. In order to better understand hearing at this initial stage, we need to know the following about spiral ganglion neurons: (1) their cell biology including cytoplasmic, cytoskeletal, and membrane properties, (2) their peripheral and central connections including synaptic structure; (3) the nature of their neural signaling; and (4) their capacity for plasticity and rehabilitation. In this report, we will update the progress on these topics and indicate important issues still awaiting resolution.
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UR - http://www.scopus.com/inward/citedby.url?scp=79960987666&partnerID=8YFLogxK
U2 - 10.1016/j.heares.2011.04.003
DO - 10.1016/j.heares.2011.04.003
M3 - Article
C2 - 21530629
AN - SCOPUS:79960987666
VL - 278
SP - 2
EP - 20
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1-2
ER -