The spectrum of clozapine response in refractory schizophrenia: Four case reports

Case reports of clozapine treatment for refractory schizophrenia have focused on instances of marked therapeutic response, raising the expectation of dramatic 'cures' and the emptying of state hospital wards. However, in clinical practice, a spectrum of response is found. This article reports four cases of varying levels of response to clinical treatment with clozapine in a state hospital, and discusses the implications of this spectrum for clinical and administrative decision makers.