The single-channel basis for the slow kinetics of synaptic currents in vertebrate slow muscle fibers

Leslie P. Henderson, Paul Brehm

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The time course of synaptic currents is significantly longer in slow than in fast twitch muscle fibers. To examine the underlying basis for these slow synaptic currents, single-channel recordings were made from the synapses of slow muscle fibers. Our analysis indicates that low conductance acetylcholine receptor (AChR) channels predominate in innervated slow fibers. The high level of expression of low conductance channels is in contrast to fast twitch fibers, in which these channels are expressed in significant numbers only in embryonic or denervated muscle. Analysis of the distribution of open durations for the low conductance channel class suggests that the open time of this AChR class is the major determinant in shaping the slow time course of synaptic current decay. The predominant contribution of low conductance channel openings to synaptic currents of slow muscle fibers indicates a well-defined physiological role for this class of AChRs.

Original languageEnglish (US)
Pages (from-to)1399-1405
Number of pages7
JournalNeuron
Volume2
Issue number4
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Vertebrates
Cholinergic Receptors
Muscles
Fast-Twitch Muscle Fibers
Synapses

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The single-channel basis for the slow kinetics of synaptic currents in vertebrate slow muscle fibers. / Henderson, Leslie P.; Brehm, Paul.

In: Neuron, Vol. 2, No. 4, 1989, p. 1399-1405.

Research output: Contribution to journalArticle

@article{8d734072dabe48a9b4237e8e06305445,
title = "The single-channel basis for the slow kinetics of synaptic currents in vertebrate slow muscle fibers",
abstract = "The time course of synaptic currents is significantly longer in slow than in fast twitch muscle fibers. To examine the underlying basis for these slow synaptic currents, single-channel recordings were made from the synapses of slow muscle fibers. Our analysis indicates that low conductance acetylcholine receptor (AChR) channels predominate in innervated slow fibers. The high level of expression of low conductance channels is in contrast to fast twitch fibers, in which these channels are expressed in significant numbers only in embryonic or denervated muscle. Analysis of the distribution of open durations for the low conductance channel class suggests that the open time of this AChR class is the major determinant in shaping the slow time course of synaptic current decay. The predominant contribution of low conductance channel openings to synaptic currents of slow muscle fibers indicates a well-defined physiological role for this class of AChRs.",
author = "Henderson, {Leslie P.} and Paul Brehm",
year = "1989",
doi = "10.1016/0896-6273(89)90078-0",
language = "English (US)",
volume = "2",
pages = "1399--1405",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - The single-channel basis for the slow kinetics of synaptic currents in vertebrate slow muscle fibers

AU - Henderson, Leslie P.

AU - Brehm, Paul

PY - 1989

Y1 - 1989

N2 - The time course of synaptic currents is significantly longer in slow than in fast twitch muscle fibers. To examine the underlying basis for these slow synaptic currents, single-channel recordings were made from the synapses of slow muscle fibers. Our analysis indicates that low conductance acetylcholine receptor (AChR) channels predominate in innervated slow fibers. The high level of expression of low conductance channels is in contrast to fast twitch fibers, in which these channels are expressed in significant numbers only in embryonic or denervated muscle. Analysis of the distribution of open durations for the low conductance channel class suggests that the open time of this AChR class is the major determinant in shaping the slow time course of synaptic current decay. The predominant contribution of low conductance channel openings to synaptic currents of slow muscle fibers indicates a well-defined physiological role for this class of AChRs.

AB - The time course of synaptic currents is significantly longer in slow than in fast twitch muscle fibers. To examine the underlying basis for these slow synaptic currents, single-channel recordings were made from the synapses of slow muscle fibers. Our analysis indicates that low conductance acetylcholine receptor (AChR) channels predominate in innervated slow fibers. The high level of expression of low conductance channels is in contrast to fast twitch fibers, in which these channels are expressed in significant numbers only in embryonic or denervated muscle. Analysis of the distribution of open durations for the low conductance channel class suggests that the open time of this AChR class is the major determinant in shaping the slow time course of synaptic current decay. The predominant contribution of low conductance channel openings to synaptic currents of slow muscle fibers indicates a well-defined physiological role for this class of AChRs.

UR - http://www.scopus.com/inward/record.url?scp=0024644591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024644591&partnerID=8YFLogxK

U2 - 10.1016/0896-6273(89)90078-0

DO - 10.1016/0896-6273(89)90078-0

M3 - Article

C2 - 2627376

AN - SCOPUS:0024644591

VL - 2

SP - 1399

EP - 1405

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 4

ER -