The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke

Wenshu Luo, Tao Liu, Shanshan Li, Hongmei Wen, Fenghua Zhou, Ross Zafonte, Xun Luo, Minghzu Xu, Randie Black-Schaffer, Lisa Wood, Yulong Wang, Qing Mei Wang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in neuroplasticity and neurogenesis following ischemic and non-ischemic brain injury. The predictive value of BDNF for short-term outcome after stroke is controversial. The objective of this study was to investigate the relationship among serum BDNF level, fractional anisotropy (FA), and functional outcome during post-acute stroke rehabilitation. Serum BDNF levels were measured on admission to an acute inpatient rehabilitation hospital. The primary functional outcome was functional independence measure (FIM) motor subscore at discharge. The secondary outcome measures were FIM total score at discharge, FIM motor subscore on admission, length of stay in the hospital, and discharge destination. We investigated the relationship among the level of serum BDNF and FA as well as functional outcome measures. Three hundred forty-eight consecutive stroke subjects were included in the analysis. Serum BDNF levels on admission were statistically but not clinically correlated with FIM motor subscore at discharge (r = 0.173, P = 0.001) and FIM total score at discharge (r = 0.155, P = 0.004). Receiver operating characteristic (ROC) analysis of BDNF as a predictor for FIM motor subscore improvement showed low accuracy of prediction with an area under the curve (AUC) of 0.581 (P = 0.026). Serum BDNF significantly correlated with FA in the high FIM motor group (n = 10, r = 0.609, P = 0.031) but not in the low FIM motor group (n = 11, r = − 0.132, P = 0.349). The serum BDNF level alone offers minimum predictive value for recovery of motor function during post-acute rehabilitation. Our findings suggest that serum BDNF level may be correlated with FA.

Original languageEnglish (US)
JournalTranslational Stroke Research
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Brain-Derived Neurotrophic Factor
Recovery of Function
Stroke
Serum
Anisotropy
Rehabilitation
Outcome Assessment (Health Care)
Neuronal Plasticity
Neurogenesis
ROC Curve
Brain Injuries
Area Under Curve
Inpatients
Length of Stay

Keywords

  • BDNF (brain-derived neurotrophic factor)
  • FA (fractional anisotropy)
  • FIM (functional independence measure)
  • Stroke rehabilitation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke. / Luo, Wenshu; Liu, Tao; Li, Shanshan; Wen, Hongmei; Zhou, Fenghua; Zafonte, Ross; Luo, Xun; Xu, Minghzu; Black-Schaffer, Randie; Wood, Lisa; Wang, Yulong; Wang, Qing Mei.

In: Translational Stroke Research, 01.01.2018.

Research output: Contribution to journalArticle

Luo, W, Liu, T, Li, S, Wen, H, Zhou, F, Zafonte, R, Luo, X, Xu, M, Black-Schaffer, R, Wood, L, Wang, Y & Wang, QM 2018, 'The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke', Translational Stroke Research. https://doi.org/10.1007/s12975-018-0648-5
Luo, Wenshu ; Liu, Tao ; Li, Shanshan ; Wen, Hongmei ; Zhou, Fenghua ; Zafonte, Ross ; Luo, Xun ; Xu, Minghzu ; Black-Schaffer, Randie ; Wood, Lisa ; Wang, Yulong ; Wang, Qing Mei. / The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke. In: Translational Stroke Research. 2018.
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AU - Luo, Wenshu

AU - Liu, Tao

AU - Li, Shanshan

AU - Wen, Hongmei

AU - Zhou, Fenghua

AU - Zafonte, Ross

AU - Luo, Xun

AU - Xu, Minghzu

AU - Black-Schaffer, Randie

AU - Wood, Lisa

AU - Wang, Yulong

AU - Wang, Qing Mei

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AB - Brain-derived neurotrophic factor (BDNF) plays an important role in neuroplasticity and neurogenesis following ischemic and non-ischemic brain injury. The predictive value of BDNF for short-term outcome after stroke is controversial. The objective of this study was to investigate the relationship among serum BDNF level, fractional anisotropy (FA), and functional outcome during post-acute stroke rehabilitation. Serum BDNF levels were measured on admission to an acute inpatient rehabilitation hospital. The primary functional outcome was functional independence measure (FIM) motor subscore at discharge. The secondary outcome measures were FIM total score at discharge, FIM motor subscore on admission, length of stay in the hospital, and discharge destination. We investigated the relationship among the level of serum BDNF and FA as well as functional outcome measures. Three hundred forty-eight consecutive stroke subjects were included in the analysis. Serum BDNF levels on admission were statistically but not clinically correlated with FIM motor subscore at discharge (r = 0.173, P = 0.001) and FIM total score at discharge (r = 0.155, P = 0.004). Receiver operating characteristic (ROC) analysis of BDNF as a predictor for FIM motor subscore improvement showed low accuracy of prediction with an area under the curve (AUC) of 0.581 (P = 0.026). Serum BDNF significantly correlated with FA in the high FIM motor group (n = 10, r = 0.609, P = 0.031) but not in the low FIM motor group (n = 11, r = − 0.132, P = 0.349). The serum BDNF level alone offers minimum predictive value for recovery of motor function during post-acute rehabilitation. Our findings suggest that serum BDNF level may be correlated with FA.

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