The sequential effects of estrogen administration and hypertension on cardiac function in ewes

S. L. Jacobson, A. Eicher, M. S. Paul, George Giraud, M. J. Morton, Kent Thornburg

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    OBJECTIVE: Our objective was to study the effect of estrogen administration and moderate hypertension on left ventricular size, pump function, and contractility in chronically instrumented ewes. STUDY DESIGN: Ewes were either given 0.06 mg/kg 17β-estradiol intramuscularly (n = 8) or were made hypertensive (n = 6) by inflation of an occluder around the aorta and were studied weekly. After 3 weeks each ewe received the opposite treatment. RESULTS: Estrogen administration caused an increase in left ventricular chamber size at a given pressure, fractional shortening (21.9% ± 2.9% to 28.5% ± 3.7%), and stroke volume (1.4 ± 0.3 mL/kg to 1.6 ± 0.3 mL/kg). Subsequent hypertension further increased left ventricular size at a given pressure but decreased fractional shortening (20.0% ± 4.4%) and stroke volume (1.3 ± 0.3 mL/kg). With hypertension first, there was no left ventricular enlargement, even with subsequent estrogen administration, and there were no changes in left ventricular pump function. End-systolic pressure and stress-dimension relationships did not change with either treatment. The end-systolic wall stress-fractional shortening relationship was likewise unchanged, suggesting that neither treatment changed contractility. CONCLUSIONS: The left ventricle previously exposed to hypertension does not remodel when exposed to estrogen, and cardiac pump function decreases when the estrogen enlarged heart is faced with moderate, subacute hypertension.

    Original languageEnglish (US)
    Pages (from-to)610-619
    Number of pages10
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume179
    Issue number3 I
    DOIs
    StatePublished - 1998

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    Estrogens
    Hypertension
    Stroke Volume
    Pressure
    Economic Inflation
    Cardiomegaly
    Left Ventricular Function
    Heart Ventricles
    Aorta
    Estradiol
    Blood Pressure

    Keywords

    • Cardiac remodeling
    • Pregnancy
    • Sex steroid
    • Sheep

    ASJC Scopus subject areas

    • Medicine(all)
    • Obstetrics and Gynecology

    Cite this

    The sequential effects of estrogen administration and hypertension on cardiac function in ewes. / Jacobson, S. L.; Eicher, A.; Paul, M. S.; Giraud, George; Morton, M. J.; Thornburg, Kent.

    In: American Journal of Obstetrics and Gynecology, Vol. 179, No. 3 I, 1998, p. 610-619.

    Research output: Contribution to journalArticle

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    abstract = "OBJECTIVE: Our objective was to study the effect of estrogen administration and moderate hypertension on left ventricular size, pump function, and contractility in chronically instrumented ewes. STUDY DESIGN: Ewes were either given 0.06 mg/kg 17β-estradiol intramuscularly (n = 8) or were made hypertensive (n = 6) by inflation of an occluder around the aorta and were studied weekly. After 3 weeks each ewe received the opposite treatment. RESULTS: Estrogen administration caused an increase in left ventricular chamber size at a given pressure, fractional shortening (21.9{\%} ± 2.9{\%} to 28.5{\%} ± 3.7{\%}), and stroke volume (1.4 ± 0.3 mL/kg to 1.6 ± 0.3 mL/kg). Subsequent hypertension further increased left ventricular size at a given pressure but decreased fractional shortening (20.0{\%} ± 4.4{\%}) and stroke volume (1.3 ± 0.3 mL/kg). With hypertension first, there was no left ventricular enlargement, even with subsequent estrogen administration, and there were no changes in left ventricular pump function. End-systolic pressure and stress-dimension relationships did not change with either treatment. The end-systolic wall stress-fractional shortening relationship was likewise unchanged, suggesting that neither treatment changed contractility. CONCLUSIONS: The left ventricle previously exposed to hypertension does not remodel when exposed to estrogen, and cardiac pump function decreases when the estrogen enlarged heart is faced with moderate, subacute hypertension.",
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    T1 - The sequential effects of estrogen administration and hypertension on cardiac function in ewes

    AU - Jacobson, S. L.

    AU - Eicher, A.

    AU - Paul, M. S.

    AU - Giraud, George

    AU - Morton, M. J.

    AU - Thornburg, Kent

    PY - 1998

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    N2 - OBJECTIVE: Our objective was to study the effect of estrogen administration and moderate hypertension on left ventricular size, pump function, and contractility in chronically instrumented ewes. STUDY DESIGN: Ewes were either given 0.06 mg/kg 17β-estradiol intramuscularly (n = 8) or were made hypertensive (n = 6) by inflation of an occluder around the aorta and were studied weekly. After 3 weeks each ewe received the opposite treatment. RESULTS: Estrogen administration caused an increase in left ventricular chamber size at a given pressure, fractional shortening (21.9% ± 2.9% to 28.5% ± 3.7%), and stroke volume (1.4 ± 0.3 mL/kg to 1.6 ± 0.3 mL/kg). Subsequent hypertension further increased left ventricular size at a given pressure but decreased fractional shortening (20.0% ± 4.4%) and stroke volume (1.3 ± 0.3 mL/kg). With hypertension first, there was no left ventricular enlargement, even with subsequent estrogen administration, and there were no changes in left ventricular pump function. End-systolic pressure and stress-dimension relationships did not change with either treatment. The end-systolic wall stress-fractional shortening relationship was likewise unchanged, suggesting that neither treatment changed contractility. CONCLUSIONS: The left ventricle previously exposed to hypertension does not remodel when exposed to estrogen, and cardiac pump function decreases when the estrogen enlarged heart is faced with moderate, subacute hypertension.

    AB - OBJECTIVE: Our objective was to study the effect of estrogen administration and moderate hypertension on left ventricular size, pump function, and contractility in chronically instrumented ewes. STUDY DESIGN: Ewes were either given 0.06 mg/kg 17β-estradiol intramuscularly (n = 8) or were made hypertensive (n = 6) by inflation of an occluder around the aorta and were studied weekly. After 3 weeks each ewe received the opposite treatment. RESULTS: Estrogen administration caused an increase in left ventricular chamber size at a given pressure, fractional shortening (21.9% ± 2.9% to 28.5% ± 3.7%), and stroke volume (1.4 ± 0.3 mL/kg to 1.6 ± 0.3 mL/kg). Subsequent hypertension further increased left ventricular size at a given pressure but decreased fractional shortening (20.0% ± 4.4%) and stroke volume (1.3 ± 0.3 mL/kg). With hypertension first, there was no left ventricular enlargement, even with subsequent estrogen administration, and there were no changes in left ventricular pump function. End-systolic pressure and stress-dimension relationships did not change with either treatment. The end-systolic wall stress-fractional shortening relationship was likewise unchanged, suggesting that neither treatment changed contractility. CONCLUSIONS: The left ventricle previously exposed to hypertension does not remodel when exposed to estrogen, and cardiac pump function decreases when the estrogen enlarged heart is faced with moderate, subacute hypertension.

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