The second filter's second coming

Sripriya Ramamoorthy, Fangyi Chen, Dingjun Zha, Steven Jacques, Ruikang Wang, Niloy Choudhoury, Alfred Nuttall, Anders Fridberger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We measured sound-evoked vibrations at the stereociliary side of inner and outer hair cells and their surrounding supporting cells, using optical coherence tomography interferometry in living anesthetized Guinea pigs. Our measurements demonstrate a gradient in frequency tuning among different cell types, going from a high best frequency at the inner hair cells to a lower one at the Hensen cells. This causes the locus of maximum inner hair cell activation to be shifted toward the apex of the cochlea as compared to the outer hair cells. These observations show that additional processing and filtering of acoustic signals occurs within the organ of Corti prior to inner hair cell excitation, thus reinstating a transformed second filter as a mechanism contributing to cochlear frequency tuning.

Original languageEnglish (US)
Title of host publicationMechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing
PublisherAmerican Institute of Physics Inc.
Volume1703
ISBN (Electronic)9780735413504
DOIs
StatePublished - Dec 31 2015
Event12th International Workshop on the Mechanics of Hearing: Protein to Perception - Cape Sounio, Greece
Duration: Jun 23 2014Jun 29 2014

Other

Other12th International Workshop on the Mechanics of Hearing: Protein to Perception
CountryGreece
CityCape Sounio
Period6/23/146/29/14

Fingerprint

hair
filters
cells
tuning
guinea pigs
cochlea
acoustics
loci
organs
interferometry
apexes
tomography
activation
vibration
gradients
causes
excitation

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Ramamoorthy, S., Chen, F., Zha, D., Jacques, S., Wang, R., Choudhoury, N., ... Fridberger, A. (2015). The second filter's second coming. In Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing (Vol. 1703). [040003] American Institute of Physics Inc.. https://doi.org/10.1063/1.4939337

The second filter's second coming. / Ramamoorthy, Sripriya; Chen, Fangyi; Zha, Dingjun; Jacques, Steven; Wang, Ruikang; Choudhoury, Niloy; Nuttall, Alfred; Fridberger, Anders.

Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. Vol. 1703 American Institute of Physics Inc., 2015. 040003.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ramamoorthy, S, Chen, F, Zha, D, Jacques, S, Wang, R, Choudhoury, N, Nuttall, A & Fridberger, A 2015, The second filter's second coming. in Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. vol. 1703, 040003, American Institute of Physics Inc., 12th International Workshop on the Mechanics of Hearing: Protein to Perception, Cape Sounio, Greece, 6/23/14. https://doi.org/10.1063/1.4939337
Ramamoorthy S, Chen F, Zha D, Jacques S, Wang R, Choudhoury N et al. The second filter's second coming. In Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. Vol. 1703. American Institute of Physics Inc. 2015. 040003 https://doi.org/10.1063/1.4939337
Ramamoorthy, Sripriya ; Chen, Fangyi ; Zha, Dingjun ; Jacques, Steven ; Wang, Ruikang ; Choudhoury, Niloy ; Nuttall, Alfred ; Fridberger, Anders. / The second filter's second coming. Mechanics of Hearing: Protein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing. Vol. 1703 American Institute of Physics Inc., 2015.
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