The second filter's second coming

Sripriya Ramamoorthy, Fangyi Chen, Dingjun Zha, Steven L. Jacques, Ruikang Wang, Niloy Choudhoury, Alfred L. Nuttall, Anders Fridberger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We measured sound-evoked vibrations at the stereociliary side of inner and outer hair cells and their surrounding supporting cells, using optical coherence tomography interferometry in living anesthetized Guinea pigs. Our measurements demonstrate a gradient in frequency tuning among different cell types, going from a high best frequency at the inner hair cells to a lower one at the Hensen cells. This causes the locus of maximum inner hair cell activation to be shifted toward the apex of the cochlea as compared to the outer hair cells. These observations show that additional processing and filtering of acoustic signals occurs within the organ of Corti prior to inner hair cell excitation, thus reinstating a transformed second filter as a mechanism contributing to cochlear frequency tuning.

Original languageEnglish (US)
Title of host publicationMechanics of Hearing
Subtitle of host publicationProtein to Perception - Proceedings of the 12th International Workshop on the Mechanics of Hearing
EditorsDavid P. Corey, K. Domenica Karavitaki
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413504
DOIs
StatePublished - Dec 31 2015
Event12th International Workshop on the Mechanics of Hearing: Protein to Perception - Cape Sounio, Greece
Duration: Jun 23 2014Jun 29 2014

Publication series

NameAIP Conference Proceedings
Volume1703
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other12th International Workshop on the Mechanics of Hearing: Protein to Perception
Country/TerritoryGreece
CityCape Sounio
Period6/23/146/29/14

ASJC Scopus subject areas

  • General Physics and Astronomy

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