The scoop on the fly brain: Glial engulfment functions in Drosophila

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Glial cells provide support and protection for neurons in the embryonic and adult brain, mediated in part through the phagocytic activity of glia. Glial cells engulf apoptotic cells and pruned neurites from the developing nervous system, and also clear degenerating neuronal debris from the adult brain after neural trauma. Studies indicate that Drosophila melanogaster is an ideal model system to elucidate the mechanisms of engulfment by glia. The recent studies reviewed here show that many features of glial engulfment are conserved across species and argue that work in Drosophila will provide valuable cellular and molecular insight into glial engulfment activity in mammals.

Original languageEnglish (US)
Pages (from-to)63-74
Number of pages12
JournalNeuron Glia Biology
Volume3
Issue number1
DOIs
StatePublished - Feb 1 2007

Keywords

  • Drosophila glia
  • Phagocyte
  • Phagocytosis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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