The safety assessment of fragrance materials

David R. Bickers, Peter Calow, Helmut A. Greim, Jon Hanifin, Adrianne E. Rogers, Jean Hilaire Saurat, I. Glenn Sipes, Robert L. Smith, Hachiro Tagami

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions.

Original languageEnglish (US)
Pages (from-to)218-273
Number of pages56
JournalRegulatory Toxicology and Pharmacology
Volume37
Issue number2
DOIs
StatePublished - Apr 2003

Fingerprint

Fragrances
Safety
Industry
Decision Trees
Skin
Risk Management
Research
Publications
Decision trees
Risk management
Toxicity
Hazards

ASJC Scopus subject areas

  • Toxicology

Cite this

Bickers, D. R., Calow, P., Greim, H. A., Hanifin, J., Rogers, A. E., Saurat, J. H., ... Tagami, H. (2003). The safety assessment of fragrance materials. Regulatory Toxicology and Pharmacology, 37(2), 218-273. https://doi.org/10.1016/S0273-2300(03)00003-5

The safety assessment of fragrance materials. / Bickers, David R.; Calow, Peter; Greim, Helmut A.; Hanifin, Jon; Rogers, Adrianne E.; Saurat, Jean Hilaire; Sipes, I. Glenn; Smith, Robert L.; Tagami, Hachiro.

In: Regulatory Toxicology and Pharmacology, Vol. 37, No. 2, 04.2003, p. 218-273.

Research output: Contribution to journalArticle

Bickers, DR, Calow, P, Greim, HA, Hanifin, J, Rogers, AE, Saurat, JH, Sipes, IG, Smith, RL & Tagami, H 2003, 'The safety assessment of fragrance materials', Regulatory Toxicology and Pharmacology, vol. 37, no. 2, pp. 218-273. https://doi.org/10.1016/S0273-2300(03)00003-5
Bickers, David R. ; Calow, Peter ; Greim, Helmut A. ; Hanifin, Jon ; Rogers, Adrianne E. ; Saurat, Jean Hilaire ; Sipes, I. Glenn ; Smith, Robert L. ; Tagami, Hachiro. / The safety assessment of fragrance materials. In: Regulatory Toxicology and Pharmacology. 2003 ; Vol. 37, No. 2. pp. 218-273.
@article{1a5625f6343e4aec856d8e615c32e773,
title = "The safety assessment of fragrance materials",
abstract = "Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions.",
author = "Bickers, {David R.} and Peter Calow and Greim, {Helmut A.} and Jon Hanifin and Rogers, {Adrianne E.} and Saurat, {Jean Hilaire} and Sipes, {I. Glenn} and Smith, {Robert L.} and Hachiro Tagami",
year = "2003",
month = "4",
doi = "10.1016/S0273-2300(03)00003-5",
language = "English (US)",
volume = "37",
pages = "218--273",
journal = "Regulatory Toxicology and Pharmacology",
issn = "0273-2300",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - The safety assessment of fragrance materials

AU - Bickers, David R.

AU - Calow, Peter

AU - Greim, Helmut A.

AU - Hanifin, Jon

AU - Rogers, Adrianne E.

AU - Saurat, Jean Hilaire

AU - Sipes, I. Glenn

AU - Smith, Robert L.

AU - Tagami, Hachiro

PY - 2003/4

Y1 - 2003/4

N2 - Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions.

AB - Safety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. In prior publications the research priorities used by the Research Institute for Fragrance Materials (RIFM), and the methods of exposure estimation used by industry have been summarized. This paper provides details of the approach used by the RIFM Expert Panel (REXPAN), to examine the dermal effects, systemic toxicity and environmental consequences of the use of and exposure to fragrance materials, which allow a reliable determination of safe use under intended conditions. The key to the usefulness of this analysis is the grouping of more than 2600 discrete ingredients into classes, based on chemical structures. Research sponsored by RIFM, data supplied by member companies, and relevant published reports from many sources are all considered during hazard characterization. A discussion is provided of REXPAN's decision tree approach to assessing the dermal, systemic and environmental endpoints and the types and quality of data included. This overall process results in well-documented conclusions which are provided to the International Fragrance Association (IFRA) as the basis for consideration of a new or existing Fragrance Material Standard and to industry for appropriate product risk management actions.

UR - http://www.scopus.com/inward/record.url?scp=0037395707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037395707&partnerID=8YFLogxK

U2 - 10.1016/S0273-2300(03)00003-5

DO - 10.1016/S0273-2300(03)00003-5

M3 - Article

C2 - 12726755

AN - SCOPUS:0037395707

VL - 37

SP - 218

EP - 273

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

IS - 2

ER -