The roles of local interneurons in the processing of olfactory information in the antennal lobes of the moth Manduca sexta.

J. G. Hildebrand, T. A. Christensen, I. D. Harrow, U. Homberg, Steven Matsumoto, B. R. Waldrop

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The antennal lobe (AL) of the sphinx month Manduca sexta is characterized by a typically glomerular neuropil and two principal classes to neurons local interneurons and projection neurons. The somata of these neurons reside in defined neural cell-body groups in the AL, and the neurons exhibit characteristic patterns of innervation of the glomeruli. Evidence gathered to date indicates that individual antennal olfactory receptor-cell axons project to single glomeruli in the ipsilateral AL and make excitatory, apparently cholinergic synapses with neurites of AL neurons (usually local neurons) innervating the target glomeruli. Much has been learned about the physiology of the projection neurons, but only recently have the physiological properties and functions of the local interneurons been examined systematically through the use of intracellular recording and staining methods. Immunocytochemical studies have shown that most of the local interneurons contain GABA as well as one or more putative neuropeptides. Physiological, pharmacological, and biochemical experiments support the view that GABAergic local interneurons are responsible for inhibitory synaptic inputs to projection neurons that predominate in shaping the activity of projection neurons conveying synaptically processed olfactory information to higher-order centers in the protocerebrum.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalActa Biologica Hungarica
Volume43
Issue number1-4
StatePublished - 1992
Externally publishedYes

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antennal lobe
Manduca
Moths
interneurons
Manduca sexta
Interneurons
Automatic Data Processing
moth
Neurons
physiology
moths
neurons
Processing
experiment
Odorant Receptors
Olfactory Receptor Neurons
project
method
Sphinx
Neuropil

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Hildebrand, J. G., Christensen, T. A., Harrow, I. D., Homberg, U., Matsumoto, S., & Waldrop, B. R. (1992). The roles of local interneurons in the processing of olfactory information in the antennal lobes of the moth Manduca sexta. Acta Biologica Hungarica, 43(1-4), 167-174.

The roles of local interneurons in the processing of olfactory information in the antennal lobes of the moth Manduca sexta. / Hildebrand, J. G.; Christensen, T. A.; Harrow, I. D.; Homberg, U.; Matsumoto, Steven; Waldrop, B. R.

In: Acta Biologica Hungarica, Vol. 43, No. 1-4, 1992, p. 167-174.

Research output: Contribution to journalArticle

Hildebrand, JG, Christensen, TA, Harrow, ID, Homberg, U, Matsumoto, S & Waldrop, BR 1992, 'The roles of local interneurons in the processing of olfactory information in the antennal lobes of the moth Manduca sexta.', Acta Biologica Hungarica, vol. 43, no. 1-4, pp. 167-174.
Hildebrand, J. G. ; Christensen, T. A. ; Harrow, I. D. ; Homberg, U. ; Matsumoto, Steven ; Waldrop, B. R. / The roles of local interneurons in the processing of olfactory information in the antennal lobes of the moth Manduca sexta. In: Acta Biologica Hungarica. 1992 ; Vol. 43, No. 1-4. pp. 167-174.
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