The role of the spleen in ischemic stroke

Keith R. Pennypacker, Halina Offner

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.

Original languageEnglish (US)
Pages (from-to)186-187
Number of pages2
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number2
StatePublished - Feb 2 2015


  • brain ischemia
  • macrophages
  • neuroinflammation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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