The role of the spleen in ischemic stroke

Keith R. Pennypacker, Halina Offner

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.

Original languageEnglish (US)
Pages (from-to)186-187
Number of pages2
JournalJournal of Cerebral Blood Flow and Metabolism
Volume35
Issue number2
DOIs
StatePublished - Feb 2 2015

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Spleen
Stroke
Literature

Keywords

  • brain ischemia
  • macrophages
  • neuroinflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

The role of the spleen in ischemic stroke. / Pennypacker, Keith R.; Offner, Halina.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 35, No. 2, 02.02.2015, p. 186-187.

Research output: Contribution to journalArticle

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