The role of the melanocortin-3 receptor in cachexia

Daniel Marks, Roger D. Cone

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cachexia refers to a synergistic combination of a dramatic decrease in appetite and an increase in metabolism of fat and lean body mass. This combination is found in a number of chronic diseases and is an important determinant of mortality. In this paper, we provide evidence that in both acute and chronic disease models, blockade of the MC4-R results in a dramatic attenuation of cachexia. We have also demonstrated that blockade of the melanocortin-3 receptor (MC3-R) leads to enhanced disease-associated cachexia. Ultimately, this work may lead to investigation of drug therapy for this widespread medical problem.

Original languageEnglish (US)
Pages (from-to)258-266
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume994
StatePublished - 2003

Fingerprint

Receptor, Melanocortin, Type 3
Cachexia
Chronic Disease
Drug therapy
Acute Disease
Appetite
Medical problems
Metabolism
Fats
Drug Therapy
Mortality

Keywords

  • Appetite
  • Cachexia
  • Cancer
  • Melanocortin
  • Proopiomelanocortin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The role of the melanocortin-3 receptor in cachexia. / Marks, Daniel; Cone, Roger D.

In: Annals of the New York Academy of Sciences, Vol. 994, 2003, p. 258-266.

Research output: Contribution to journalArticle

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