The role of the melanocortin-3 receptor in cachexia

Daniel L. Marks, Roger D. Cone

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Cachexia refers to a synergistic combination of a dramatic decrease in appetite and an increase in metabolism of fat and lean body mass. This combination is found in a number of chronic diseases and is an important determinant of mortality. In this paper, we provide evidence that in both acute and chronic disease models, blockade of the MC4-R results in a dramatic attenuation of cachexia. We have also demonstrated that blockade of the melanocortin-3 receptor (MC3-R) leads to enhanced disease-associated cachexia. Ultimately, this work may lead to investigation of drug therapy for this widespread medical problem.

Original languageEnglish (US)
Pages (from-to)258-266
Number of pages9
JournalAnnals of the New York Academy of Sciences
StatePublished - Jan 1 2003


  • Appetite
  • Cachexia
  • Cancer
  • Melanocortin
  • Proopiomelanocortin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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