The Role of the Immune System in the Effects of Cancer on Bone

Rebecca Silbermann, Garson David Roodman

Research output: Chapter in Book/Report/Conference proceedingChapter


In this chapter, the contributions of cells in the immune system (monocyte-macrophages, myeloid derived suppressor cells, mesenchymal stromal cells, T cell subsets, NK cells, dendritic cells, and B cells) to bone metastasis, and multiple myeloma bone disease will be reviewed. In addition, the effects of tumor-derived products, such as lactic acid, that is also produced by bone cells, on the suppression of antitumor responses that are required for tumor growth in bone, will be discussed. All of these components of the immune system are major contributors to the growth and bone altering effects of tumor cells in bone.

Original languageEnglish (US)
Title of host publicationOsteoimmunology
Subtitle of host publicationInteractions of the Immune and Skeletal Systems: Second Edition
PublisherElsevier Inc.
Number of pages14
ISBN (Print)9780128005712
StatePublished - 2016
Externally publishedYes


  • Dendritic cells
  • Immune system
  • Macrophage
  • Metastasis
  • Multiple myeloma
  • Tumor cells

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


Dive into the research topics of 'The Role of the Immune System in the Effects of Cancer on Bone'. Together they form a unique fingerprint.

Cite this