Abstract
In this chapter, the contributions of cells in the immune system (monocyte-macrophages, myeloid derived suppressor cells, mesenchymal stromal cells, T cell subsets, NK cells, dendritic cells, and B cells) to bone metastasis, and multiple myeloma bone disease will be reviewed. In addition, the effects of tumor-derived products, such as lactic acid, that is also produced by bone cells, on the suppression of antitumor responses that are required for tumor growth in bone, will be discussed. All of these components of the immune system are major contributors to the growth and bone altering effects of tumor cells in bone.
| Original language | English (US) |
|---|---|
| Title of host publication | Osteoimmunology |
| Subtitle of host publication | Interactions of the Immune and Skeletal Systems: Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 311-324 |
| Number of pages | 14 |
| ISBN (Print) | 9780128005712 |
| DOIs | |
| State | Published - 2016 |
| Externally published | Yes |
Keywords
- Dendritic cells
- Immune system
- Macrophage
- Metastasis
- Multiple myeloma
- Tumor cells
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology