The crucial role of autoreactive T cells in mediating the development and propagation of AITD seems irrefutable. Although study of phenotypic lymphocyte analysis has not directly led to our basic understanding of the processes involved, studies assessing functional characteristics of intrathyroidal lymphocytes have been extremely useful. There is firm evidence that T lymphocytes are sensitized to thyroid antigens, and we believe future studies should focus on this interaction between 'thyroid antigens' and the lymphocyte 'OKT3' receptor that leads to lymphocytic proliferation.
|Original language||English (US)|
|Number of pages||40|
|Journal||Endocrinology and Metabolism Clinics of North America|
|State||Published - Dec 1 1987|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism