The role of T lymphocytes in autoimmune thyroid disease

A. J. Ahmann, K. D. Burman

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

The crucial role of autoreactive T cells in mediating the development and propagation of AITD seems irrefutable. Although study of phenotypic lymphocyte analysis has not directly led to our basic understanding of the processes involved, studies assessing functional characteristics of intrathyroidal lymphocytes have been extremely useful. There is firm evidence that T lymphocytes are sensitized to thyroid antigens, and we believe future studies should focus on this interaction between 'thyroid antigens' and the lymphocyte 'OKT3' receptor that leads to lymphocytic proliferation.

Original languageEnglish (US)
Pages (from-to)287-326
Number of pages40
JournalEndocrinology and Metabolism Clinics of North America
Volume16
Issue number2
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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