The role of T lymphocytes in autoimmune thyroid disease

Andrew Ahmann, K. D. Burman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The crucial role of autoreactive T cells in mediating the development and propagation of AITD seems irrefutable. Although study of phenotypic lymphocyte analysis has not directly led to our basic understanding of the processes involved, studies assessing functional characteristics of intrathyroidal lymphocytes have been extremely useful. There is firm evidence that T lymphocytes are sensitized to thyroid antigens, and we believe future studies should focus on this interaction between 'thyroid antigens' and the lymphocyte 'OKT3' receptor that leads to lymphocytic proliferation.

Original languageEnglish (US)
Pages (from-to)287-326
Number of pages40
JournalEndocrinology and Metabolism Clinics of North America
Volume16
Issue number2
StatePublished - 1987
Externally publishedYes

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T-cells
Lymphocytes
Thyroid Diseases
Autoimmune Diseases
T-Lymphocytes
Thyroid Gland
Antigens
Muromonab-CD3

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

The role of T lymphocytes in autoimmune thyroid disease. / Ahmann, Andrew; Burman, K. D.

In: Endocrinology and Metabolism Clinics of North America, Vol. 16, No. 2, 1987, p. 287-326.

Research output: Contribution to journalArticle

Ahmann, Andrew ; Burman, K. D. / The role of T lymphocytes in autoimmune thyroid disease. In: Endocrinology and Metabolism Clinics of North America. 1987 ; Vol. 16, No. 2. pp. 287-326.
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