The role of T cells in autoimmune uveitis

Research output: Contribution to journalShort survey

29 Scopus citations

Abstract

Autoimmune diseases result from the activation of self-reactive T cells recognizing autoantigens or foreign antigens cross-reactive with an autoantigen. T cells are thought to play a major role in autoimmune diseases in different organs, including the eye. This review focuses on the role of T cells in autoimmune uveitis in humans and in animal models of experimental autoimmune uveitis. Since rheumatoid arthritis is an autoimmune disease that has been studied far more extensively than uveitis, we have also included a review of clinical and experimental observations relevant to that disease.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalOcular Immunology and Inflammation
Volume8
Issue number2
StatePublished - Jan 1 2000

Keywords

  • Autoimmunity
  • Experimental uveitis
  • Pathomechanisms
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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