The role of starburst amacrine cells in visual signal processing

W. R. Taylor, R. G. Smith

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Starburst amacrine cells (SBACs) within the adult mammalian retina provide the critical inhibition that underlies the receptive field properties of direction-selective ganglion cells (DSGCs). The SBACs generate direction-selective output of GABA that differentially inhibits the DSGCs. We review the biophysical mechanisms that produce directional GABA release from SBACs and test a network model that predicts the effects of reciprocal inhibition between adjacent SBACs. The results of the model simulations suggest that reciprocal inhibitory connections between closely spaced SBACs should be spatially selective, while connections between more widely spaced cells could be indiscriminate. SBACs were initially identified as cholinergic neurons and were subsequently shown to contain release both acetylcholine and GABA. While the role of the GABAergic transmission is well established, the role of the cholinergic transmission remains unclear.

Original languageEnglish (US)
Pages (from-to)73-81
Number of pages9
JournalVisual neuroscience
Volume29
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Computational model
  • Direction selectivity
  • Gabaergic inhibition
  • Retina
  • Visual system

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems

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