The role of purinergic receptors in retinal function and disease

Michelle M. Ward, Teresa Puthussery, Kirstan A. Vessey, Erica L. Fletcher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Extracellular ATP acts as a neurotransmitter in the central and peripheral nervous systems. In this review, the role of purinergic receptors in neuronal signaling and bi-directional glial-neuronal communication in the retina will be considered. There is growing evidence that a range of P2X and P2Y receptors are expressed on most classes of retinal neurons and that activation of P2 receptors modulates retinal function. Furthermore, neuronal control of glial function is achieved through neuronal release of ATP and activation of P2Y receptors expressed by Müller cells. Altered purinergic signaling in Müller cells has been implicated in gliotic changes in the diseased retina and furthermore, elevations in extracellular ATP may lead to apoptosis of retinal neurons.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages385-391
Number of pages7
Volume664
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume664
ISSN (Print)00652598

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Purinergic Receptors
Retinal Diseases
Retinal Neurons
Adenosine Triphosphate
Neuroglia
Neurons
Retina
Chemical activation
Peripheral Nervous System
Neurology
Neurotransmitter Agents
Central Nervous System
Apoptosis
Communication

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ward, M. M., Puthussery, T., Vessey, K. A., & Fletcher, E. L. (2010). The role of purinergic receptors in retinal function and disease. In Advances in Experimental Medicine and Biology (Vol. 664, pp. 385-391). (Advances in Experimental Medicine and Biology; Vol. 664). https://doi.org/10.1007/978-1-4419-1399-9_44

The role of purinergic receptors in retinal function and disease. / Ward, Michelle M.; Puthussery, Teresa; Vessey, Kirstan A.; Fletcher, Erica L.

Advances in Experimental Medicine and Biology. Vol. 664 2010. p. 385-391 (Advances in Experimental Medicine and Biology; Vol. 664).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ward, MM, Puthussery, T, Vessey, KA & Fletcher, EL 2010, The role of purinergic receptors in retinal function and disease. in Advances in Experimental Medicine and Biology. vol. 664, Advances in Experimental Medicine and Biology, vol. 664, pp. 385-391. https://doi.org/10.1007/978-1-4419-1399-9_44
Ward MM, Puthussery T, Vessey KA, Fletcher EL. The role of purinergic receptors in retinal function and disease. In Advances in Experimental Medicine and Biology. Vol. 664. 2010. p. 385-391. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-1399-9_44
Ward, Michelle M. ; Puthussery, Teresa ; Vessey, Kirstan A. ; Fletcher, Erica L. / The role of purinergic receptors in retinal function and disease. Advances in Experimental Medicine and Biology. Vol. 664 2010. pp. 385-391 (Advances in Experimental Medicine and Biology).
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