The role of proteoglycans in the nanoindentation creep behavior of human dentin

Luiz Bertassoni, Matheus Kury, Catherine Rathsam, Christopher B. Little, Michael V. Swain

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Attempts to understand the mechanical behavior of dentin and other mineralized tissues have been primarily focused on the role of their more abundant matrix components, such as collagen and hydroxyapatite. The structural mechanisms endowing these biological materials with outstanding load bearing properties, however, remain elusive to date. Furthermore, while their response to deformation has been extensively studied, mechanisms contributing to their recovery from induced deformation remain poorly described in the literature. Here, we offer novel insights into the participation of proteoglycans (PG) and glycosaminoglycans (GAG) in regulating the nanoindentation creep deformation and recovery of mineralized and demineralized dentin. Accordingly, after the enzymatic digestion of either PGs and associated GAGs or only GAGs, the nanoindentation creep deformation of dentin increased significantly, while the relative recovery of both the mineralized and demineralized dentin dropped by 40-70%. In summary, our results suggest that PGs and GAGs may participate in a nanoscale mechanism that contributes significantly to the outstanding durability of dentin and possibly other mineralized tissues of similar composition.

Original languageEnglish (US)
Pages (from-to)264-270
Number of pages7
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume55
DOIs
StatePublished - Mar 1 2015

Fingerprint

Proteoglycans
Nanoindentation
Creep
Recovery
Bearings (structural)
Tissue
Durapatite
Glycosaminoglycans
Hydroxyapatite
Collagen
Biological materials
Durability
Chemical analysis

Keywords

  • Bone
  • Collagen
  • Dentin
  • Glycosaminoglycans
  • Nanoindentation
  • Proteoglycans

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

Cite this

The role of proteoglycans in the nanoindentation creep behavior of human dentin. / Bertassoni, Luiz; Kury, Matheus; Rathsam, Catherine; Little, Christopher B.; Swain, Michael V.

In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 55, 01.03.2015, p. 264-270.

Research output: Contribution to journalArticle

Bertassoni, Luiz ; Kury, Matheus ; Rathsam, Catherine ; Little, Christopher B. ; Swain, Michael V. / The role of proteoglycans in the nanoindentation creep behavior of human dentin. In: Journal of the Mechanical Behavior of Biomedical Materials. 2015 ; Vol. 55. pp. 264-270.
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