Biologically-based cancer risk assessmsent relies on mathematical models that represent the toxicokinetics and toxicodynamics of the xenobiotic in the body. Physiologically-based toxicokinetic (PBTK) models are used as a tool for predicting the target tissue of dose a xenobiotic from different routes of exposure, extrapolating from high doses to low doses and extrapolating between species. This paper reviews the role of PBTK models and their limitations in biologically-based risk assessment.
|Original language||English (US)|
|Number of pages||2|
|Journal||Folia Histochemica et Cytobiologica|
|Issue number||SUPPL. 2|
|State||Published - Jan 1 2001|
ASJC Scopus subject areas
- Pathology and Forensic Medicine