The role of physiologically based toxicokinetic models in biologically based risk assessment

Karen Watanabe-Sailor, C. Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Biologically-based cancer risk assessmsent relies on mathematical models that represent the toxicokinetics and toxicodynamics of the xenobiotic in the body. Physiologically-based toxicokinetic (PBTK) models are used as a tool for predicting the target tissue of dose a xenobiotic from different routes of exposure, extrapolating from high doses to low doses and extrapolating between species. This paper reviews the role of PBTK models and their limitations in biologically-based risk assessment.

Original languageEnglish (US)
Pages (from-to)50-51
Number of pages2
JournalFolia Histochemica et Cytobiologica
Volume39
Issue numberSUPPL. 2
StatePublished - 2001
Externally publishedYes

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Xenobiotics
Theoretical Models
Toxicokinetics
Neoplasms

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

The role of physiologically based toxicokinetic models in biologically based risk assessment. / Watanabe-Sailor, Karen; Chen, C.

In: Folia Histochemica et Cytobiologica, Vol. 39, No. SUPPL. 2, 2001, p. 50-51.

Research output: Contribution to journalArticle

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