The role of physiologically based toxicokinetic models in biologically based risk assessment

Karen Watanabe-Sailor, C. Chen

Research output: Contribution to journalArticle

1 Scopus citations


Biologically-based cancer risk assessmsent relies on mathematical models that represent the toxicokinetics and toxicodynamics of the xenobiotic in the body. Physiologically-based toxicokinetic (PBTK) models are used as a tool for predicting the target tissue of dose a xenobiotic from different routes of exposure, extrapolating from high doses to low doses and extrapolating between species. This paper reviews the role of PBTK models and their limitations in biologically-based risk assessment.

Original languageEnglish (US)
Pages (from-to)50-51
Number of pages2
JournalFolia Histochemica et Cytobiologica
Issue numberSUPPL. 2
Publication statusPublished - 2001
Externally publishedYes


ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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