The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

Simon Chiu, Michel A. Woodbury-Fariña, Mujeeb Shad, Mariwan Husni, John Copen, Yves Bureau, Zack Cernovsky, J. Jurui Hou, Hana Raheb, Kristen Terpstra, Veronica Sanchez, Ana Hategan, Mike Kaushal, Robbie Campbell

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.

    Original languageEnglish (US)
    Pages (from-to)591-623
    Number of pages33
    JournalPsychiatric Clinics of North America
    Volume37
    Issue number4
    DOIs
    StatePublished - Dec 1 2014

    Fingerprint

    Epigenomics
    Alzheimer Disease
    Food
    Dietary Supplements
    Diet
    Cognition
    Blood Vessels
    Buffers
    Health
    Brain
    Genes

    Keywords

    • Alzheimer dementia
    • Cognition
    • Epigenetics diet
    • Nutraceuticals
    • Stress

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Medicine(all)

    Cite this

    The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease. / Chiu, Simon; Woodbury-Fariña, Michel A.; Shad, Mujeeb; Husni, Mariwan; Copen, John; Bureau, Yves; Cernovsky, Zack; Hou, J. Jurui; Raheb, Hana; Terpstra, Kristen; Sanchez, Veronica; Hategan, Ana; Kaushal, Mike; Campbell, Robbie.

    In: Psychiatric Clinics of North America, Vol. 37, No. 4, 01.12.2014, p. 591-623.

    Research output: Contribution to journalArticle

    Chiu, S, Woodbury-Fariña, MA, Shad, M, Husni, M, Copen, J, Bureau, Y, Cernovsky, Z, Hou, JJ, Raheb, H, Terpstra, K, Sanchez, V, Hategan, A, Kaushal, M & Campbell, R 2014, 'The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease', Psychiatric Clinics of North America, vol. 37, no. 4, pp. 591-623. https://doi.org/10.1016/j.psc.2014.09.001
    Chiu, Simon ; Woodbury-Fariña, Michel A. ; Shad, Mujeeb ; Husni, Mariwan ; Copen, John ; Bureau, Yves ; Cernovsky, Zack ; Hou, J. Jurui ; Raheb, Hana ; Terpstra, Kristen ; Sanchez, Veronica ; Hategan, Ana ; Kaushal, Mike ; Campbell, Robbie. / The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease. In: Psychiatric Clinics of North America. 2014 ; Vol. 37, No. 4. pp. 591-623.
    @article{a4169c162ce04970a2b9d55160786ee0,
    title = "The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease",
    abstract = "Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.",
    keywords = "Alzheimer dementia, Cognition, Epigenetics diet, Nutraceuticals, Stress",
    author = "Simon Chiu and Woodbury-Fari{\~n}a, {Michel A.} and Mujeeb Shad and Mariwan Husni and John Copen and Yves Bureau and Zack Cernovsky and Hou, {J. Jurui} and Hana Raheb and Kristen Terpstra and Veronica Sanchez and Ana Hategan and Mike Kaushal and Robbie Campbell",
    year = "2014",
    month = "12",
    day = "1",
    doi = "10.1016/j.psc.2014.09.001",
    language = "English (US)",
    volume = "37",
    pages = "591--623",
    journal = "Psychiatric Clinics of North America",
    issn = "0193-953X",
    publisher = "W.B. Saunders Ltd",
    number = "4",

    }

    TY - JOUR

    T1 - The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

    AU - Chiu, Simon

    AU - Woodbury-Fariña, Michel A.

    AU - Shad, Mujeeb

    AU - Husni, Mariwan

    AU - Copen, John

    AU - Bureau, Yves

    AU - Cernovsky, Zack

    AU - Hou, J. Jurui

    AU - Raheb, Hana

    AU - Terpstra, Kristen

    AU - Sanchez, Veronica

    AU - Hategan, Ana

    AU - Kaushal, Mike

    AU - Campbell, Robbie

    PY - 2014/12/1

    Y1 - 2014/12/1

    N2 - Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.

    AB - Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.

    KW - Alzheimer dementia

    KW - Cognition

    KW - Epigenetics diet

    KW - Nutraceuticals

    KW - Stress

    UR - http://www.scopus.com/inward/record.url?scp=84921885725&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84921885725&partnerID=8YFLogxK

    U2 - 10.1016/j.psc.2014.09.001

    DO - 10.1016/j.psc.2014.09.001

    M3 - Article

    VL - 37

    SP - 591

    EP - 623

    JO - Psychiatric Clinics of North America

    JF - Psychiatric Clinics of North America

    SN - 0193-953X

    IS - 4

    ER -