The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

Simon Chiu, Michel A. Woodbury-Fariña, Mujeeb U. Shad, Mariwan Husni, John Copen, Yves Bureau, Zack Cernovsky, J. Jurui Hou, Hana Raheb, Kristen Terpstra, Veronica Sanchez, Ana Hategan, Mike Kaushal, Robbie Campbell

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.

Original languageEnglish (US)
Pages (from-to)591-623
Number of pages33
JournalPsychiatric Clinics of North America
Volume37
Issue number4
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Alzheimer dementia
  • Cognition
  • Epigenetics diet
  • Nutraceuticals
  • Stress

ASJC Scopus subject areas

  • Psychiatry and Mental health

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