The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

Simon Chiu; Michel A. Woodbury-Fariña; Mujeeb U. Shad; Mariwan Husni; John Copen; Yves Bureau; Zack Cernovsky; J. Jurui Hou; Hana Raheb; Kristen Terpstra; Veronica Sanchez; Ana Hategan; Mike Kaushal; Robbie Campbell

doi:10.1016/j.psc.2014.09.001

The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

Simon Chiu, Michel A. Woodbury-Fariña, Mujeeb U. Shad, Mariwan Husni, John Copen, Yves Bureau, Zack Cernovsky, J. Jurui Hou, Hana Raheb, Kristen Terpstra, Veronica Sanchez, Ana Hategan, Mike Kaushal, Robbie Campbell

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.

Original language	English (US)
Pages (from-to)	591-623
Number of pages	33
Journal	Psychiatric Clinics of North America
Volume	37
Issue number	4
DOIs	https://doi.org/10.1016/j.psc.2014.09.001
State	Published - Dec 1 2014

Keywords

Alzheimer dementia
Cognition
Epigenetics diet
Nutraceuticals
Stress

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1016/j.psc.2014.09.001

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Chiu, S., Woodbury-Fariña, M. A., Shad, M. U., Husni, M., Copen, J., Bureau, Y., Cernovsky, Z., Hou, J. J., Raheb, H., Terpstra, K., Sanchez, V., Hategan, A., Kaushal, M., & Campbell, R. (2014). The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease. Psychiatric Clinics of North America, 37(4), 591-623. https://doi.org/10.1016/j.psc.2014.09.001

Chiu, S, Woodbury-Fariña, MA, Shad, MU, Husni, M, Copen, J, Bureau, Y, Cernovsky, Z, Hou, JJ, Raheb, H, Terpstra, K, Sanchez, V, Hategan, A, Kaushal, M & Campbell, R 2014, 'The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease', Psychiatric Clinics of North America, vol. 37, no. 4, pp. 591-623. https://doi.org/10.1016/j.psc.2014.09.001

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abstract = "Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.",

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AU - Copen, John

AU - Bureau, Yves

AU - Cernovsky, Zack

AU - Hou, J. Jurui

AU - Raheb, Hana

AU - Terpstra, Kristen

AU - Sanchez, Veronica

AU - Hategan, Ana

AU - Kaushal, Mike

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AB - Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.

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The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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