The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

Simon Chiu, Michel A. Woodbury-Fariña, Mujeeb U. Shad, Mariwan Husni, John Copen, Yves Bureau, Zack Cernovsky, J. Jurui Hou, Hana Raheb, Kristen Terpstra, Veronica Sanchez, Ana Hategan, Mike Kaushal, Robbie Campbell

    Research output: Contribution to journalReview article

    11 Scopus citations

    Abstract

    Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.

    Original languageEnglish (US)
    Pages (from-to)591-623
    Number of pages33
    JournalPsychiatric Clinics of North America
    Volume37
    Issue number4
    DOIs
    StatePublished - Dec 1 2014

    Keywords

    • Alzheimer dementia
    • Cognition
    • Epigenetics diet
    • Nutraceuticals
    • Stress

    ASJC Scopus subject areas

    • Psychiatry and Mental health

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  • Cite this

    Chiu, S., Woodbury-Fariña, M. A., Shad, M. U., Husni, M., Copen, J., Bureau, Y., Cernovsky, Z., Hou, J. J., Raheb, H., Terpstra, K., Sanchez, V., Hategan, A., Kaushal, M., & Campbell, R. (2014). The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease. Psychiatric Clinics of North America, 37(4), 591-623. https://doi.org/10.1016/j.psc.2014.09.001