The role of NFκB in healthy and preeclamptic placenta: Trophoblasts in the spotlight

Brooke Armistead; Leena Kadam; Sascha Drewlo; Hamid Reza Kohan-Ghadr

doi:10.3390/ijms21051775

The role of NFκB in healthy and preeclamptic placenta: Trophoblasts in the spotlight

Brooke Armistead, Leena Kadam, Sascha Drewlo, Hamid Reza Kohan-Ghadr

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention.

Original language	English (US)
Article number	1775
Journal	International journal of molecular sciences
Volume	21
Issue number	5
DOIs	https://doi.org/10.3390/ijms21051775
State	Published - Mar 1 2020
Externally published	Yes

Keywords

Nuclear factor kappa-B
Placenta
Preeclampsia
Pregnancy
Trophoblast

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms21051775

Cite this

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abstract = "The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention.",

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The role of NFκB in healthy and preeclamptic placenta: Trophoblasts in the spotlight

Abstract

Keywords

ASJC Scopus subject areas

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