The role of molecular pathology in the diagnosis of cutaneous lymphomas

Philipp W. Raess, Adam Bagg

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in the evaluation of cutaneous lymphoproliferations. The biologic basis of ARGR studies is discussed, as well as a comparison of various current protocols. The pitfalls and limitations of ARGR analysis are also highlighted. Recent advances in the understanding of the molecular pathogenesis of various cutaneous lymphomas are discussed. Some of these nascent discoveries may lead to the development of diagnostically useful molecular assays.

Original languageEnglish (US)
Article number913523
JournalPathology Research International
Volume2012
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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