Characterization of the IGF system in cultured prostatic epithelial and stromal cells has established a model for the biological role of IGFs in the prostate. The specific components of the IGF system differ between the stroma and the epithelium, and they may differ among normal, BPH, and malignant tissues. Abnormalities in the IGF system that have been observed in stromal cells derived from BPH may provide a basis for the etiology of BPH and for new therapeutic strategies. Several abnormalities in the IGF system, including increased IGFBP-2 and decreased IGFBP-3 in sera, may be associated with prostate cancer. Furthermore, PSA may cause increased mitogenic activity of IGF by cleavage of IGFBP-3 in local areas surrounding prostate cancer at either primary or metastic sites. Future studies will aim to validate these models in vivo by in situ hybridization, immunohistochemistry, and other techniques.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Andrology|
|Publication status||Published - Jan 1996|
ASJC Scopus subject areas