The role of insulin-like growth factors in prostate biology

Donna M. Peehl, Pinchas Cohen, Ronald (Ron) Rosenfeld

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Characterization of the IGF system in cultured prostatic epithelial and stromal cells has established a model for the biological role of IGFs in the prostate. The specific components of the IGF system differ between the stroma and the epithelium, and they may differ among normal, BPH, and malignant tissues. Abnormalities in the IGF system that have been observed in stromal cells derived from BPH may provide a basis for the etiology of BPH and for new therapeutic strategies. Several abnormalities in the IGF system, including increased IGFBP-2 and decreased IGFBP-3 in sera, may be associated with prostate cancer. Furthermore, PSA may cause increased mitogenic activity of IGF by cleavage of IGFBP-3 in local areas surrounding prostate cancer at either primary or metastic sites. Future studies will aim to validate these models in vivo by in situ hybridization, immunohistochemistry, and other techniques.

Original languageEnglish (US)
Pages (from-to)2-4
Number of pages3
JournalJournal of Andrology
Volume17
Issue number1
StatePublished - Jan 1996

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Insulin-Like Growth Factor Binding Protein 3
Somatomedins
Stromal Cells
Prostate
Prostatic Neoplasms
Insulin-Like Growth Factor Binding Protein 2
Biological Models
In Situ Hybridization
Epithelium
Epithelial Cells
Immunohistochemistry
Serum
Therapeutics

ASJC Scopus subject areas

  • Endocrinology

Cite this

Peehl, D. M., Cohen, P., & Rosenfeld, R. R. (1996). The role of insulin-like growth factors in prostate biology. Journal of Andrology, 17(1), 2-4.

The role of insulin-like growth factors in prostate biology. / Peehl, Donna M.; Cohen, Pinchas; Rosenfeld, Ronald (Ron).

In: Journal of Andrology, Vol. 17, No. 1, 01.1996, p. 2-4.

Research output: Contribution to journalArticle

Peehl, DM, Cohen, P & Rosenfeld, RR 1996, 'The role of insulin-like growth factors in prostate biology', Journal of Andrology, vol. 17, no. 1, pp. 2-4.
Peehl DM, Cohen P, Rosenfeld RR. The role of insulin-like growth factors in prostate biology. Journal of Andrology. 1996 Jan;17(1):2-4.
Peehl, Donna M. ; Cohen, Pinchas ; Rosenfeld, Ronald (Ron). / The role of insulin-like growth factors in prostate biology. In: Journal of Andrology. 1996 ; Vol. 17, No. 1. pp. 2-4.
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