The Role of Insulin-like Growth Factors in Diabetic Kidney Disease

Derek LeRoith, Haim Werner, Moshe Phillip, Charles T. Roberts

    Research output: Contribution to journalArticle

    19 Scopus citations

    Abstract

    Early renal manifestations of type I diabetes include kidney enlargement, increased glomerular filtration rate, and renal plasma flow. These hemodynamic changes may be caused by a number of factors, including growth hormone and/or insulin-like growth factor-I (IGF-I). Streptozotocin-induced insulinopenic diabetes in rats represents a model of human type I diabetes and is associated with the early hemodynamic changes in the kidney seen in poorly controlled type I diabetic patients. These changes are preceded by an accumulation of IGF-I peptide in the kidney. Insulin-like growth factor-I is not locally produced, but rather accumulates from circulating IGF-I, trapped by increased levels of IGF-binding proteins, particularly IGF-binding protein-1. The hemodynamic effects, reproduced by infusions of recombinant human IGF-I in normal rats, may be blocked by co-infusion of a kinin-receptor antagonist, suggesting that at least one of the mechanisms involved is the kallikrein-kinin system. These studies strongly support the notion that the IGF system may play a role in early hemodynamic manifestations of the diabetic kidney. Whether these effects lead to long-term diabetic renal disease remains to be studied.

    Original languageEnglish (US)
    Pages (from-to)722-726
    Number of pages5
    JournalAmerican Journal of Kidney Diseases
    Volume22
    Issue number5
    DOIs
    StatePublished - Jan 1 1993

    Keywords

    • Diabetic
    • insulin-like growth factors
    • renal
    • renal plasma flow

    ASJC Scopus subject areas

    • Nephrology

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