The role of insulin-like growth factors in diabetic kidney disease

D. LeRoith, H. Werner, M. Phillip, Charles Roberts

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Early renal manifestations of type I diabetes include kidney enlargement, increased glomerular filtration rate, and renal plasma flow. These hemodynamic changes may be caused by a number of factors, including growth hormone and/or insulin-like growth factor-I (IGF-I). Streptozotocin-induced insulinopenic diabetes in rats represents a model of human type I diabetes and is associated with the early hemodynamic changes in the kidney seen in poorly controlled type I diabetic patients. These changes are preceded by an accumulation of IGF-I peptide in the kidney. Insulin-like growth factor-I is not locally produced, but rather accumulates from circulating IGF-I, trapped by increased levels of IGF-binding proteins, particularly IGF-binding protein-1. The hemodynamic effects, reproduced by infusions of recombinant human IGF-I in normal rats, may be blocked by co-infusion of a kinin- receptor antagonist, suggesting that at least one of the mechanisms involved is the kallikrein-kinin system. These studies strongly support the notion that the IGF system may play a role in early hemodynamic manifestations of the diabetic kidney. Whether these effects lead to long-term diabetic renal disease remains to be studied.

Original languageEnglish (US)
Pages (from-to)722-726
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume22
Issue number5
StatePublished - 1993
Externally publishedYes

Fingerprint

Diabetic Nephropathies
Somatomedins
Insulin-Like Growth Factor I
Kidney
Hemodynamics
Type 1 Diabetes Mellitus
Kallikrein-Kinin System
Renal Plasma Flow
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Proteins
Kinins
Streptozocin
Glomerular Filtration Rate
Growth Hormone
Peptides

ASJC Scopus subject areas

  • Nephrology

Cite this

The role of insulin-like growth factors in diabetic kidney disease. / LeRoith, D.; Werner, H.; Phillip, M.; Roberts, Charles.

In: American Journal of Kidney Diseases, Vol. 22, No. 5, 1993, p. 722-726.

Research output: Contribution to journalArticle

LeRoith, D. ; Werner, H. ; Phillip, M. ; Roberts, Charles. / The role of insulin-like growth factors in diabetic kidney disease. In: American Journal of Kidney Diseases. 1993 ; Vol. 22, No. 5. pp. 722-726.
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