The role of HLA-G in gastrointestinal inflammatory disease and malignancy

Erinn Downs-Kelly, Andrew E. Schade, Donna E. Hansel

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Human leukocyte antigen (HLA)-G has been shown to act as an immune-inhibitory molecule and to interfere with the normal functions of natural killer (NK) cells and T-cells, conferring a potential route for HLA-G expressing cells to escape host immune surveillance. These findings have led to the rather intense study of HLA-G expression in several different arenas, including organ transplantation, inflammatory conditions, and in a wide variety of neoplasms including hematolymphoid neoplasms, visceral carcinomas, gliomas, and dermal-based neoplasms. This review will focus on the role of HLA-G in inflammatory conditions of the bowel, which can serve as an initiator of neoplastic alterations, as well as examine HLA-G expression and function in a variety of gastrointestinal malignancies. Although there are only a limited number of studies that have examined HLA-G in the gastrointestinal tract, the role of HLA-G has been controversial in this organ system with conflicting results reported even within the same tumor type.

Original languageEnglish (US)
Pages (from-to)451-458
Number of pages8
JournalSeminars in Cancer Biology
Volume17
Issue number6
DOIs
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • Adenoma
  • Carcinoma
  • Colon
  • Gastrointestinal tract
  • HLA-G
  • Inflammatory bowel disease
  • Pancreas

ASJC Scopus subject areas

  • Cancer Research

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