The role of growth in heart development

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    11 Citations (Scopus)

    Abstract

    While it is established that the quality of the perinatal environment is critical in sculpting the developing individual, the mechanisms by which this occurs remain poorly defined. The growing fetus is dependent on the nutrients (including oxygen) it receives from the mother via the placenta. When this supply line is compromised, heart growth patterns are altered. In addition, hormones, other circulating factors, and the hemodynamic environment in which the fetus develops are important in determining outcomes for organ structure and function. Numerous studies in sheep have demonstrated that heart development can be modified in a number of ways, and the nature of the change differs between types and gestational timings of insults. Embolization of the placenta leads to the cessation of proliferation and maturation of cardiomyocytes; this may be due in part to changes in circulating insulin-like growth factor-1 levels. Such insults may be the underlying cause of cardiovascular disease in adults. Insults that modify the maturational timeline, final myocyte number, vascularity and endothelial responsiveness in the heart can have effects that persist long after the insult has been ameliorated.

    Original languageEnglish (US)
    Title of host publicationNestle Nutrition Workshop Series: Pediatric Program
    Pages39-48
    Number of pages10
    Volume61
    DOIs
    StatePublished - 2008

    Publication series

    NameNestle Nutrition Workshop Series: Pediatric Program
    Volume61
    ISSN (Print)16616677
    ISSN (Electronic)16623878

    Fingerprint

    heart
    placenta
    Placenta
    fetus
    Fetus
    Growth
    somatomedins
    Somatomedins
    hemodynamics
    Cardiac Myocytes
    myocytes
    Muscle Cells
    cardiovascular diseases
    Sheep
    Cardiovascular Diseases
    Hemodynamics
    hormones
    Hormones
    Oxygen
    oxygen

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Food Science
    • Nutrition and Dietetics

    Cite this

    Thornburg, K., Louey, S., & Giraud, G. (2008). The role of growth in heart development. In Nestle Nutrition Workshop Series: Pediatric Program (Vol. 61, pp. 39-48). (Nestle Nutrition Workshop Series: Pediatric Program; Vol. 61). https://doi.org/10.1159/000113169

    The role of growth in heart development. / Thornburg, Kent; Louey, Samantha; Giraud, George.

    Nestle Nutrition Workshop Series: Pediatric Program. Vol. 61 2008. p. 39-48 (Nestle Nutrition Workshop Series: Pediatric Program; Vol. 61).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Thornburg, K, Louey, S & Giraud, G 2008, The role of growth in heart development. in Nestle Nutrition Workshop Series: Pediatric Program. vol. 61, Nestle Nutrition Workshop Series: Pediatric Program, vol. 61, pp. 39-48. https://doi.org/10.1159/000113169
    Thornburg K, Louey S, Giraud G. The role of growth in heart development. In Nestle Nutrition Workshop Series: Pediatric Program. Vol. 61. 2008. p. 39-48. (Nestle Nutrition Workshop Series: Pediatric Program). https://doi.org/10.1159/000113169
    Thornburg, Kent ; Louey, Samantha ; Giraud, George. / The role of growth in heart development. Nestle Nutrition Workshop Series: Pediatric Program. Vol. 61 2008. pp. 39-48 (Nestle Nutrition Workshop Series: Pediatric Program).
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