The role of glutamate transporters in glutamate homeostasis in the brain

Michiko Takahashi, Brian Billups, David Rossi, Monique Sarantis, Martine Hamann, David Attwell

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Glutamate transporters in neurones and glia, four of which have been cloned from mammals, play a crucial rule in controlling the extracellular glutamate concentration in the brain. In normal conditions, they remove glutamate from the extracellular space and thereby help to terminate glutamatergic synaptic transmission and to prevent the extracellular glutamate concentration from rising to neurotoxic values. Glutamate transport on these carriers is thought to be driven by the cotransport of Na+, the countertransport of K+, and either the cotransport of H+ or the counter-transport of OH-. Activating the transporters also activates an anion conductance in their structure, the anion flux through which is not coupled to glutamate movement and varies widely for the different transporters. During hypoxia or ischaemia, glutamate transporters can run backwards, releasing glutamate into the extracellular space, triggering the death of neurones and thus causing mental and physical handicap. The rate of glutamate release by this process is slowed by the acid pH occurring in hypoxia/ischaemia, which may help protect the brain during transient, but not sustained, ischaemia.

Original languageEnglish (US)
Pages (from-to)401-409
Number of pages9
JournalJournal of Experimental Biology
Volume200
Issue number2
StatePublished - Jan 1997
Externally publishedYes

Fingerprint

Amino Acid Transport System X-AG
homeostasis
hypoxia
glutamates
transporters
brain
anion
Glutamic Acid
Homeostasis
Brain
mammal
ischemia
Ischemia
Extracellular Space
acid
extracellular space
Anions
anions
Neurons
neurons

Keywords

  • anion conductance
  • cloning
  • epilepsy
  • glial cell
  • glutamate transporter
  • hypoxia
  • ischaemia
  • neurone
  • pH
  • postsynaptic uptake
  • stoichiometry
  • synaptic transmission

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Takahashi, M., Billups, B., Rossi, D., Sarantis, M., Hamann, M., & Attwell, D. (1997). The role of glutamate transporters in glutamate homeostasis in the brain. Journal of Experimental Biology, 200(2), 401-409.

The role of glutamate transporters in glutamate homeostasis in the brain. / Takahashi, Michiko; Billups, Brian; Rossi, David; Sarantis, Monique; Hamann, Martine; Attwell, David.

In: Journal of Experimental Biology, Vol. 200, No. 2, 01.1997, p. 401-409.

Research output: Contribution to journalArticle

Takahashi, M, Billups, B, Rossi, D, Sarantis, M, Hamann, M & Attwell, D 1997, 'The role of glutamate transporters in glutamate homeostasis in the brain', Journal of Experimental Biology, vol. 200, no. 2, pp. 401-409.
Takahashi M, Billups B, Rossi D, Sarantis M, Hamann M, Attwell D. The role of glutamate transporters in glutamate homeostasis in the brain. Journal of Experimental Biology. 1997 Jan;200(2):401-409.
Takahashi, Michiko ; Billups, Brian ; Rossi, David ; Sarantis, Monique ; Hamann, Martine ; Attwell, David. / The role of glutamate transporters in glutamate homeostasis in the brain. In: Journal of Experimental Biology. 1997 ; Vol. 200, No. 2. pp. 401-409.
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