The role of fatty acid desaturases in epidermal metabolism

Harini Sampath, James M. Ntambi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The lipid composition of skin is important to a variety of functions served by this organ. Therefore, skin expresses multiple enzymes that synthesize and metabolize lipids. An important class of lipid metabolism enzymes expressed in skin is the lipid desaturases. Various isoforms of stearoyl-CoA desaturase, a delta-9 desaturase, as well as a delta-6 desaturase alter the lipid composition of the skin, thereby affecting skin barrier homeostasis and consequently, whole body energy balance. This review will focus on the role of fatty acid desaturases in maintaining epidermal metabolism.

Original languageEnglish (US)
Pages (from-to)62-64
Number of pages3
JournalDermato-Endocrinology
Volume3
Issue number2
DOIs
StatePublished - Apr 2011

Fingerprint

Fatty Acid Desaturases
Skin
Stearoyl-CoA Desaturase
Lipids
Linoleoyl-CoA Desaturase
Enzymes
Lipid Metabolism
Protein Isoforms
Homeostasis

Keywords

  • Energy balance
  • Sebaceous lipids
  • Sebocyte hypoplasia
  • Skin barrier
  • Skin lipids

ASJC Scopus subject areas

  • Dermatology
  • Endocrinology, Diabetes and Metabolism

Cite this

The role of fatty acid desaturases in epidermal metabolism. / Sampath, Harini; Ntambi, James M.

In: Dermato-Endocrinology, Vol. 3, No. 2, 04.2011, p. 62-64.

Research output: Contribution to journalArticle

Sampath, Harini ; Ntambi, James M. / The role of fatty acid desaturases in epidermal metabolism. In: Dermato-Endocrinology. 2011 ; Vol. 3, No. 2. pp. 62-64.
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