The role of fatty acid desaturases in epidermal metabolism

Harini Sampath, James M. Ntambi

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

The lipid composition of skin is important to a variety of functions served by this organ. Therefore, skin expresses multiple enzymes that synthesize and metabolize lipids. An important class of lipid metabolism enzymes expressed in skin is the lipid desaturases. Various isoforms of stearoyl-CoA desaturase, a delta-9 desaturase, as well as a delta-6 desaturase alter the lipid composition of the skin, thereby affecting skin barrier homeostasis and consequently, whole body energy balance. This review will focus on the role of fatty acid desaturases in maintaining epidermal metabolism.

Original languageEnglish (US)
Pages (from-to)62-64
Number of pages3
JournalDermato-Endocrinology
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2011

Keywords

  • Energy balance
  • Sebaceous lipids
  • Sebocyte hypoplasia
  • Skin barrier
  • Skin lipids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Dermatology

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