The role of docosahexaenoic acid in retinal function

B. G. Jeffrey, H. S. Weisinger, Martha Neuringer, D. C. Mitchell

    Research output: Contribution to journalArticle

    97 Citations (Scopus)

    Abstract

    An important role for docosahexaenoic acid (DHA) within the retina is suggested by its high levels and active conservation in this tissue. Animals raised on n-3-deficient diets have large reductions in retinal DHA levels that are associated with altered retinal function as assessed by the electroretinogram (ERG). Despite two decades of research in this field, little is known about the mechanisms underlying altered retinal function in n-3-deficient animals. The focus of this review is on recent research that has sought to elucidate the role of DHA in retinal function, particularly within the rod photoreceptor outer segments where DHA is found at its highest concentration. An overview is also given of human infant studies that have examined whether a neonatal dietary supply of DHA is required for the normal development of retinal function.

    Original languageEnglish (US)
    Pages (from-to)859-871
    Number of pages13
    JournalLipids
    Volume36
    Issue number9
    StatePublished - 2001

    Fingerprint

    Docosahexaenoic Acids
    docosahexaenoic acid
    Animals
    Rod Cell Outer Segment
    rods (retina)
    Retinal Rod Photoreceptor Cells
    electroretinography
    Nutrition
    retina
    Research
    Retina
    Conservation
    animals
    Tissue
    Diet
    diet

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Food Science
    • Biochemistry

    Cite this

    Jeffrey, B. G., Weisinger, H. S., Neuringer, M., & Mitchell, D. C. (2001). The role of docosahexaenoic acid in retinal function. Lipids, 36(9), 859-871.

    The role of docosahexaenoic acid in retinal function. / Jeffrey, B. G.; Weisinger, H. S.; Neuringer, Martha; Mitchell, D. C.

    In: Lipids, Vol. 36, No. 9, 2001, p. 859-871.

    Research output: Contribution to journalArticle

    Jeffrey, BG, Weisinger, HS, Neuringer, M & Mitchell, DC 2001, 'The role of docosahexaenoic acid in retinal function', Lipids, vol. 36, no. 9, pp. 859-871.
    Jeffrey BG, Weisinger HS, Neuringer M, Mitchell DC. The role of docosahexaenoic acid in retinal function. Lipids. 2001;36(9):859-871.
    Jeffrey, B. G. ; Weisinger, H. S. ; Neuringer, Martha ; Mitchell, D. C. / The role of docosahexaenoic acid in retinal function. In: Lipids. 2001 ; Vol. 36, No. 9. pp. 859-871.
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