The role of docosahexaenoic acid in retinal function

Brett G. Jeffrey, Harrison S. Weisinger, Martha Neuringer, Drake C. Mitchell

    Research output: Contribution to journalArticlepeer-review

    119 Scopus citations


    An important role for docosahexaenoic acid (DHA) within the retina is suggested by its high levels and active conservation in this tissue. Animals raised on n-3-deficient diets have large reductions in retinal DHA levels that are associated with altered retinal function as assessed by the electroretinogram (ERG). Despite two decades of research in this field, little is known about the mechanisms underlying altered retinal function in n-3-deficient animals. The focus of this review is on recent research that has sought to elucidate the role of DHA in retinal function, particularly within the rod photoreceptor outer segments where DHA is found at its highest concentration. An overview is also given of human infant studies that have examined whether a neonatal dietary supply of DHA is required for the normal development of retinal function.

    Original languageEnglish (US)
    Article number796
    Pages (from-to)859-871
    Number of pages13
    Issue number9
    StatePublished - 2001

    ASJC Scopus subject areas

    • Biochemistry
    • Organic Chemistry
    • Cell Biology


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