The role of CuCu dinuclear complexes in the oxidation of ascorbic acid by O2 a model for copper-oxidase activity

R. F. Jameson, Ninian Blackburn

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The copper(II) catalysed oxidation of ascorbate by molecular oxygen has been re-investigated. The kinetics require that electron transfer from a dinuclear copper-ascorbate complex to dioxygen be invoked as the initial step in the mechanism in nitrate, fluoride and chloride media, the reaction thus being presumed to go through a higher, rather than a lower, oxidation state intermediate. The catalytic mechanism of copper-oxidases is discussed in terms of this 'model' system, the former also containing CuCu dinuclear units as oxygen binding sites.

Original languageEnglish (US)
Pages (from-to)809-814
Number of pages6
JournalJournal of Inorganic and Nuclear Chemistry
Volume37
Issue number3
DOIs
StatePublished - 1975
Externally publishedYes

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ascorbic acid
Ascorbic acid
oxidase
Ascorbic Acid
Copper
Oxygen
copper
Oxidation
oxidation
Molecular oxygen
Fluorides
Nitrates
Chlorides
Binding Sites
oxygen
Binding sites
Kinetics
fluorides
nitrates
Electrons

Cite this

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abstract = "The copper(II) catalysed oxidation of ascorbate by molecular oxygen has been re-investigated. The kinetics require that electron transfer from a dinuclear copper-ascorbate complex to dioxygen be invoked as the initial step in the mechanism in nitrate, fluoride and chloride media, the reaction thus being presumed to go through a higher, rather than a lower, oxidation state intermediate. The catalytic mechanism of copper-oxidases is discussed in terms of this 'model' system, the former also containing CuCu dinuclear units as oxygen binding sites.",
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T1 - The role of CuCu dinuclear complexes in the oxidation of ascorbic acid by O2 a model for copper-oxidase activity

AU - Jameson, R. F.

AU - Blackburn, Ninian

PY - 1975

Y1 - 1975

N2 - The copper(II) catalysed oxidation of ascorbate by molecular oxygen has been re-investigated. The kinetics require that electron transfer from a dinuclear copper-ascorbate complex to dioxygen be invoked as the initial step in the mechanism in nitrate, fluoride and chloride media, the reaction thus being presumed to go through a higher, rather than a lower, oxidation state intermediate. The catalytic mechanism of copper-oxidases is discussed in terms of this 'model' system, the former also containing CuCu dinuclear units as oxygen binding sites.

AB - The copper(II) catalysed oxidation of ascorbate by molecular oxygen has been re-investigated. The kinetics require that electron transfer from a dinuclear copper-ascorbate complex to dioxygen be invoked as the initial step in the mechanism in nitrate, fluoride and chloride media, the reaction thus being presumed to go through a higher, rather than a lower, oxidation state intermediate. The catalytic mechanism of copper-oxidases is discussed in terms of this 'model' system, the former also containing CuCu dinuclear units as oxygen binding sites.

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