The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche

Jacob D. Estes, Ashley T. Haase, Timothy W. Schacker

Research output: Contribution to journalReview article

65 Scopus citations


The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalSeminars in Immunology
Issue number3
StatePublished - Jun 1 2008



  • Fibrosis
  • HIV pathogenesis
  • Immune reconstitution
  • Lymphatic tissues
  • Naive CD4 cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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