Abstract
The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-186 |
| Number of pages | 6 |
| Journal | Seminars in Immunology |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1 2008 |
Keywords
- Fibrosis
- HIV pathogenesis
- Immune reconstitution
- Lymphatic tissues
- Naive CD4 cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Estes, J. D., Haase, A. T., & Schacker, T. W. (2008). The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche. Seminars in Immunology, 20(3), 181-186. https://doi.org/10.1016/j.smim.2008.04.002