The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche

Jacob Estes, Ashley T. Haase, Timothy W. Schacker

Research output: Contribution to journal › Review article

63 Citations (Scopus)

Abstract

The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalSeminars in Immunology
Volume20
Issue number3
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Fingerprint

HIV-1
Collagen
T-Lymphocytes
Infection
Opportunistic Infections
Lymphoid Tissue
HIV Infections
Cicatrix
Acquired Immunodeficiency Syndrome
Population
Neoplasms
Therapeutics

Keywords

  • Fibrosis
  • HIV pathogenesis
  • Immune reconstitution
  • Lymphatic tissues
  • Naive CD4 cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche. / Estes, Jacob; Haase, Ashley T.; Schacker, Timothy W.

In: Seminars in Immunology, Vol. 20, No. 3, 01.06.2008, p. 181-186.

Research output: Contribution to journal › Review article

Estes, J, Haase, AT & Schacker, TW 2008, 'The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche', Seminars in Immunology, vol. 20, no. 3, pp. 181-186. https://doi.org/10.1016/j.smim.2008.04.002
Estes J, Haase AT, Schacker TW. The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche. Seminars in Immunology. 2008 Jun 1;20(3):181-186. https://doi.org/10.1016/j.smim.2008.04.002
Estes, Jacob ; Haase, Ashley T. ; Schacker, Timothy W. / The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche. In: Seminars in Immunology. 2008 ; Vol. 20, No. 3. pp. 181-186.
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