Abstract
The hallmark of HIV/SIV infections is the progressive depletion of CD4+ T cells that ultimately renders the host incapable of defending against AIDS defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4+ T cell loss, we review here the growing evidence that fibrotic 'scarring' and consequent damage to the lymphatic tissue niche contributes to CD4+ T cell decline and limits CD4+ T cell re-population with retroviral therapy.
Original language | English (US) |
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Pages (from-to) | 181-186 |
Number of pages | 6 |
Journal | Seminars in Immunology |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2008 |
Keywords
- Fibrosis
- HIV pathogenesis
- Immune reconstitution
- Lymphatic tissues
- Naive CD4 cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology