The role of biopsy in the management of patients with presumed diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline

Brian T. Ragel, Timothy C. Ryken, Steven N. Kalkanis, Mateo Ziu, Daniel Cahill, Jeffrey J. Olson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Question: What is the optimal role of biopsy in the initial management of presumptive low-grade glioma in adults? Target population: Adult patients with imaging suggestive of a low-grade glioma. Recommendations: Level III: Stereotactic biopsy is recommended when definitive surgical resection is limited by lesions that are deep-seated, not resectable, and/or located within eloquent cortex, or in patients unable to undergo craniotomy due to medical co-morbidities to obtain the critical tissue diagnosis needed for targeted treatment planning for patients with low-grade gliomas. Question: What is the best technique for brain biopsy? Target population: Adult patients with imaging suggestive of a low-grade glioma. Recommendations: Level III: Frameless and frame-based stereotactic brain biopsy for low-grade gliomas are recommended based on clinical circumstances as they provide similar diagnostic yield, diagnostic accuracy, morbidity, and mortality. It is recommended the surgeon consider advanced imaging techniques (e.g., perfusion, spectroscopy, metabolic studies) to target specific regions of interest to potentially improve diagnostic accuracy.

Original languageEnglish (US)
Pages (from-to)481-501
Number of pages21
JournalJournal of Neuro-Oncology
Volume125
Issue number3
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Fingerprint

Evidence-Based Practice
Practice Guidelines
Glioma
Biopsy
Health Services Needs and Demand
Morbidity
Craniotomy
Brain
Spectrum Analysis
Perfusion
Mortality

Keywords

  • Biopsy
  • Guidelines
  • Low-grade glioma
  • Stereotactic biopsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

Cite this

The role of biopsy in the management of patients with presumed diffuse low grade glioma : A systematic review and evidence-based clinical practice guideline. / Ragel, Brian T.; Ryken, Timothy C.; Kalkanis, Steven N.; Ziu, Mateo; Cahill, Daniel; Olson, Jeffrey J.

In: Journal of Neuro-Oncology, Vol. 125, No. 3, 01.12.2015, p. 481-501.

Research output: Contribution to journalArticle

Ragel, Brian T. ; Ryken, Timothy C. ; Kalkanis, Steven N. ; Ziu, Mateo ; Cahill, Daniel ; Olson, Jeffrey J. / The role of biopsy in the management of patients with presumed diffuse low grade glioma : A systematic review and evidence-based clinical practice guideline. In: Journal of Neuro-Oncology. 2015 ; Vol. 125, No. 3. pp. 481-501.
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