The role of A-kinase anchoring proteins (AKaps) in regulating sperm function.

D. W. Carr, A. E.Hanlon Newell

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Cyclic AMP (cAMP)-dependent protein kinase (PKA) is a signalling molecule involved in the regulation of many physiological functions including those of cilia and flagella. PKA localizes to specific cellular structures and organelles by binding to AKAP (A-kinase anchoring protein) molecules via interaction with the regulatory subunits (RI and RII) of PKA. AKAPs are capable of forming multi-protein complexes to coordinate the action of several signalling molecules all at a single location. AKAPs also bind to a group of four proteins that share the RII dimerization/docking (R2D2) domain. R2D2 proteins are expressed at high levels in both the testis and spermatozoa and mutants lacking R2D2 proteins exhibit abnormal sperm motility. Thus AKAPs and AKAP associated proteins appear to be key molecules in the biochemical machinery regulating the functions of flagella and cilia.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalSociety of Reproduction and Fertility supplement
Volume63
StatePublished - 2007

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this