The Rhesus Macaque as a Model of Human Aging and Age-Related Disease

Mary Ann Ottinger, Julie M. Wu, Julie A. Mattison, George S. Roth, Mark A. Lane, Donald K. Ingram, Mary Zelinski, Steven Kohama

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1 Citation (Scopus)

    Abstract

    This chapter explains how the rhesus monkey offers an advantageous model for biomedical research because of the close relatedness of this species to humans. In the rhesus macaque, there are Chinese- and Indian-derived monkeys, with the latter being most represented in the literature. These monkeys may be considered subspecies in that they differ somewhat in their physical characteristics. There are extensive data on the maintenance of the rhesus macaque in laboratory conditions as well as in outdoor pens. Metabolic endocrine systems show age-related changes that are similar to those experienced in humans, with increasing risk of prediabetic symptoms and changing metabolic function. Body composition in rhesus also parallels changes observed in humans. Cardiovascular disease poses a major threat to aging individuals. The rhesus monkey has been used extensively in the development of diagnostic methods for cardiovascular disease. Similar to humans, postural and structural changes occur associated with diminished bone mineral density in aging rhesus monkeys. Compared to the rhesus monkey, there is no other well-characterized animal model with such extensive similarity to humans across a wide range of physiological responses.

    Original languageEnglish (US)
    Title of host publicationHandbook of Models for Human Aging
    PublisherElsevier Inc.
    Pages457-468
    Number of pages12
    ISBN (Print)9780123693914
    DOIs
    StatePublished - 2006

    Fingerprint

    Macaca mulatta
    Aging of materials
    Minerals
    Bone
    Animals
    Haplorhini
    Cardiovascular Diseases
    Chemical analysis
    Endocrine System
    Body Composition
    Bone Density
    Biomedical Research
    Animal Models
    Maintenance

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Ottinger, M. A., Wu, J. M., Mattison, J. A., Roth, G. S., Lane, M. A., Ingram, D. K., ... Kohama, S. (2006). The Rhesus Macaque as a Model of Human Aging and Age-Related Disease. In Handbook of Models for Human Aging (pp. 457-468). Elsevier Inc.. https://doi.org/10.1016/B978-012369391-4/50039-4

    The Rhesus Macaque as a Model of Human Aging and Age-Related Disease. / Ottinger, Mary Ann; Wu, Julie M.; Mattison, Julie A.; Roth, George S.; Lane, Mark A.; Ingram, Donald K.; Zelinski, Mary; Kohama, Steven.

    Handbook of Models for Human Aging. Elsevier Inc., 2006. p. 457-468.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Ottinger, MA, Wu, JM, Mattison, JA, Roth, GS, Lane, MA, Ingram, DK, Zelinski, M & Kohama, S 2006, The Rhesus Macaque as a Model of Human Aging and Age-Related Disease. in Handbook of Models for Human Aging. Elsevier Inc., pp. 457-468. https://doi.org/10.1016/B978-012369391-4/50039-4
    Ottinger MA, Wu JM, Mattison JA, Roth GS, Lane MA, Ingram DK et al. The Rhesus Macaque as a Model of Human Aging and Age-Related Disease. In Handbook of Models for Human Aging. Elsevier Inc. 2006. p. 457-468 https://doi.org/10.1016/B978-012369391-4/50039-4
    Ottinger, Mary Ann ; Wu, Julie M. ; Mattison, Julie A. ; Roth, George S. ; Lane, Mark A. ; Ingram, Donald K. ; Zelinski, Mary ; Kohama, Steven. / The Rhesus Macaque as a Model of Human Aging and Age-Related Disease. Handbook of Models for Human Aging. Elsevier Inc., 2006. pp. 457-468
    @inbook{78da4edc99a342a78375e815c9bb27f8,
    title = "The Rhesus Macaque as a Model of Human Aging and Age-Related Disease",
    abstract = "This chapter explains how the rhesus monkey offers an advantageous model for biomedical research because of the close relatedness of this species to humans. In the rhesus macaque, there are Chinese- and Indian-derived monkeys, with the latter being most represented in the literature. These monkeys may be considered subspecies in that they differ somewhat in their physical characteristics. There are extensive data on the maintenance of the rhesus macaque in laboratory conditions as well as in outdoor pens. Metabolic endocrine systems show age-related changes that are similar to those experienced in humans, with increasing risk of prediabetic symptoms and changing metabolic function. Body composition in rhesus also parallels changes observed in humans. Cardiovascular disease poses a major threat to aging individuals. The rhesus monkey has been used extensively in the development of diagnostic methods for cardiovascular disease. Similar to humans, postural and structural changes occur associated with diminished bone mineral density in aging rhesus monkeys. Compared to the rhesus monkey, there is no other well-characterized animal model with such extensive similarity to humans across a wide range of physiological responses.",
    author = "Ottinger, {Mary Ann} and Wu, {Julie M.} and Mattison, {Julie A.} and Roth, {George S.} and Lane, {Mark A.} and Ingram, {Donald K.} and Mary Zelinski and Steven Kohama",
    year = "2006",
    doi = "10.1016/B978-012369391-4/50039-4",
    language = "English (US)",
    isbn = "9780123693914",
    pages = "457--468",
    booktitle = "Handbook of Models for Human Aging",
    publisher = "Elsevier Inc.",

    }

    TY - CHAP

    T1 - The Rhesus Macaque as a Model of Human Aging and Age-Related Disease

    AU - Ottinger, Mary Ann

    AU - Wu, Julie M.

    AU - Mattison, Julie A.

    AU - Roth, George S.

    AU - Lane, Mark A.

    AU - Ingram, Donald K.

    AU - Zelinski, Mary

    AU - Kohama, Steven

    PY - 2006

    Y1 - 2006

    N2 - This chapter explains how the rhesus monkey offers an advantageous model for biomedical research because of the close relatedness of this species to humans. In the rhesus macaque, there are Chinese- and Indian-derived monkeys, with the latter being most represented in the literature. These monkeys may be considered subspecies in that they differ somewhat in their physical characteristics. There are extensive data on the maintenance of the rhesus macaque in laboratory conditions as well as in outdoor pens. Metabolic endocrine systems show age-related changes that are similar to those experienced in humans, with increasing risk of prediabetic symptoms and changing metabolic function. Body composition in rhesus also parallels changes observed in humans. Cardiovascular disease poses a major threat to aging individuals. The rhesus monkey has been used extensively in the development of diagnostic methods for cardiovascular disease. Similar to humans, postural and structural changes occur associated with diminished bone mineral density in aging rhesus monkeys. Compared to the rhesus monkey, there is no other well-characterized animal model with such extensive similarity to humans across a wide range of physiological responses.

    AB - This chapter explains how the rhesus monkey offers an advantageous model for biomedical research because of the close relatedness of this species to humans. In the rhesus macaque, there are Chinese- and Indian-derived monkeys, with the latter being most represented in the literature. These monkeys may be considered subspecies in that they differ somewhat in their physical characteristics. There are extensive data on the maintenance of the rhesus macaque in laboratory conditions as well as in outdoor pens. Metabolic endocrine systems show age-related changes that are similar to those experienced in humans, with increasing risk of prediabetic symptoms and changing metabolic function. Body composition in rhesus also parallels changes observed in humans. Cardiovascular disease poses a major threat to aging individuals. The rhesus monkey has been used extensively in the development of diagnostic methods for cardiovascular disease. Similar to humans, postural and structural changes occur associated with diminished bone mineral density in aging rhesus monkeys. Compared to the rhesus monkey, there is no other well-characterized animal model with such extensive similarity to humans across a wide range of physiological responses.

    UR - http://www.scopus.com/inward/record.url?scp=84868207803&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84868207803&partnerID=8YFLogxK

    U2 - 10.1016/B978-012369391-4/50039-4

    DO - 10.1016/B978-012369391-4/50039-4

    M3 - Chapter

    AN - SCOPUS:84868207803

    SN - 9780123693914

    SP - 457

    EP - 468

    BT - Handbook of Models for Human Aging

    PB - Elsevier Inc.

    ER -