The relationship of endometriosis and ovarian malignancy: a review

Farr Nezhat, M. Shoma Datta, Veneta Hanson, Tanja Pejovic, Ceana Nezhat, Camran Nezhat

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Objective: To review the malignant potential of endometriosis based on epidemiologic, histopathologic, and molecular data. Design: Literature review. Result(s): The pathogenesis of endometriosis remains unclear. The histopathologic development of endometriosis has undergone long-term investigation. Studies have confirmed histologic transition from benign endometriosis to ovarian malignancy, including malignant transformation of extraovarian endometriosis. The prevalence of endometriosis in patients with epithelial ovarian cancer, especially in endometrioid and clear cell types, has been confirmed to be higher than in the general population. Ovarian cancers and adjacent endometriotic lesions have shown common genetic alterations, such as PTEN, p53, and bcl gene mutations, suggesting a possible malignant genetic transition spectrum. Furthermore, endometriosis has been associated with a chronic inflammatory state leading to cytokine release. These cytokines act in a complex system in which they induce or repress their own synthesis and can cause unregulated mitotic division, growth and differentiation, and migration or apoptosis similar to malignant mechanisms. Conclusion(s): The malignant potential of endometriosis holds serious implications for management, such as the need for earlier and more meticulous surgical intervention for complete disease treatment.

Original languageEnglish (US)
Pages (from-to)1559-1570
Number of pages12
JournalFertility and Sterility
Volume90
Issue number5
DOIs
StatePublished - Nov 2008
Externally publishedYes

Fingerprint

Endometriosis
Neoplasms
Cytokines
p53 Genes
Ovarian Neoplasms
Apoptosis
Mutation
Growth
Population

Keywords

  • atypical endometriosis
  • clear cell carcinoma
  • endometrioid carcinoma
  • Endometriosis
  • malignant transformation

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

The relationship of endometriosis and ovarian malignancy : a review. / Nezhat, Farr; Datta, M. Shoma; Hanson, Veneta; Pejovic, Tanja; Nezhat, Ceana; Nezhat, Camran.

In: Fertility and Sterility, Vol. 90, No. 5, 11.2008, p. 1559-1570.

Research output: Contribution to journalArticle

Nezhat, Farr ; Datta, M. Shoma ; Hanson, Veneta ; Pejovic, Tanja ; Nezhat, Ceana ; Nezhat, Camran. / The relationship of endometriosis and ovarian malignancy : a review. In: Fertility and Sterility. 2008 ; Vol. 90, No. 5. pp. 1559-1570.
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